Gene transcription is largely regulated by sequence-specific transcription factors (TFs). The TF activity is significantly regulated by its posttranslational modifications (PTMs). TF-PTMs serve as 'molecular switchboards' that map multiple upstream signaling events, in response to various environmental perturbations, to the downstream transcriptional events. While many instances of TF-PTMs and ...

Process-Aware Information Systems (PAISs) support executions of operational processes that involve people, resources, and software applications on the basis of process models. Process models describe vast, often infinite, amounts of process instances, i.e., workflows supported by the systems. With the increasing adoption of PAISs, large process model repositories emerged in companies and public...

In real-world business processes it is often difficult to explain why some process instances take longer than usual to complete. With process mining techniques, it is possible to do an a posteriori analysis of a large number of process instances and detect the occurrence of delays, but discovering the actual cause of such delays is a different problem. For example, it may be the case that when ...

Traffic congestion has become a growing concern in cities, with both economic and environmental impacts on individuals the logistics industry. Therefore, model of freight distribution urban areas considering objectives needs to be established alleviate consequences. In this paper, multi-stage heuristic algorithm is designed for solving route planning based time-dependent arc travel durations. T...

Many classical synchronization problems such as the assembly line crew scheduling problem (ALCS), some data association or multisensor tracking can be formulated finding intra-column rearrangements for a single matrix representing costs, distances, similarities time requirements. In this paper, we consider an extension of these to case multiple matrices, reflecting various possible instances (s...