Introduction: Several studies have reported the involvement of age-related changes in the development of neuropathic pain behaviors. However, limited data are available on the role of age in establishing and maintaining chronic neuropathic pain after peripheral nerve injury. Methods: In the present study, we examined age-related neuropathic behavior among rats in 4 age groups: p...

The purpose of this study was to investigate the effects of the ethanol extract of Cynanchum wilfordii (ECW) on the blood lipid profile of hypercholesterolemic rats. Thirty 7-week-old male Sprague-Dawley rats were allowed free access to either a normal diet (AIN-93 diet), or 1% high-cholesterol diet with or without 0.5% or 1% ECW for 5 weeks. After sacrifice, the rat serum lipid profile was ana...

Dexmedetomidine, which is a selective α2-adrenoceptor agonist, was recently introduced into clinical practice for its analgesic properties. The purpose of this study was to evaluate the effects of dexmedetomidine in a vincristine-evoked neuropathic rat models. Sprague-Dawley rats were injected intraperitoneally with vincristine or saline (0.1 mg/kg/day) using a 5-day-on, 2-day-off schedule for ...

Background: Chronic administration of morphine cause physical dependence but the exact mechanism of this phenomenon remains unclear. The aim of this study is the assessment of systemic and intracerebroventricular (icv) administration of ramelteon (a melatonin receptor agonist) on morphine physical dependence. Methods: 88 adult male rats were divided into 2 major groups, namely “systematic” and ...

Developmental exposure to persistent endocrine disruptors is of a great concern. Affection adrenal hormones production by low-dose dichlorodiphenyltrichloroethane (DDT) has been revealed recently. Objective the research – investigation ultrastructural mechanisms impaired mineralocorticoid and glucocorticoid after prenatal postnatal disruptor DDT. Male Wistar rats exposed low doses DDT during de...

The study was designed to investigate the analgesic effect of aqueous leaf extract Fagara tessmannii engl using acetic acid-induced pain model in Wistar rats. Twenty rats were divided into five groups four each. Group 1 received distilled water while 2-5 0.2 ml/kg BW 0.6% intraperitoneal injection acid 30 mins after treatment with extracts and reference drug writhing counted. Rats sacrificed bl...