Objectives. To compare the pharmacodynamics and tolerabiiity of the new goserelin acetate 10.8-mg depot with the 3.6-mg depot in patients with advanced prostate cancer during the first 3 months of therapy. Methods. One hundred sixty patients were randomized in two comparative studies to receive either the 10.8-mg goserelin acetate depot every 12 weeks or the 3.6-mg goserelin acetate depot every...

There is a major resurgence of interest in brown adipose tissue (BAT) biology, particularly regarding its determinants and consequences in newborns and infants. Reliable methods for non-invasive BAT measurement in human infants have yet to be demonstrated. The current study first validates methods for quantitative BAT imaging of rodents post mortem followed by BAT excision and re-imaging of exc...

INTRODUCTION The 1-, 3- and 6- month biodegradable polymer matrix depot formulations of leuprorelin acetate (Eligard(®)/Depo-Eligard(®), Astellas Pharma Inc/BV) were shown to reduce testosterone and prostate-specific antigen levels and to be well tolerated in patients with advanced prostate cancer in several clinical trials. This study aimed at evaluating the efficacy, safety and tolerability o...

BACKGROUND Depot medroxyprogesterone acetate is the most studied injectable contraceptive and also one of the most effective methods of contraception currently available. It is reversible, its use is independent of intercourse, and can be provided by trained non-medical staff making it particularly suitable for use in developing countries. The aim of this study is to determine the socio-demogra...

The traveling salesman problem (TSP) is a well-known optimization problem in graph theory, as well as in operations research that has nowadays received much attention because of its practical applications in industrial and service problems. In this problem, a salesman starts to move from an arbitrary place called depot and after visits all of the nodes, finally comes back to the depot. The obje...

Thirty-two patients treated for B12 defidetected in 5 of 12 patients given two ciency with one or two initial depot series depot series 1-3 mo apart, while antiof five i.m. injections of 1 mg hydroxocobody to TC II detectable only after the balamin on alternate days followed by more sensitive immunoelectrophoresis i.m. injection of 1 mg hydroxocobalamin occurred in 2 of 20 patients given one ev...

The simplification of current vaccine administration regimes is of crucial interest in order to further sustain and expand the high impact of vaccines for public health. Most vaccines including the vaccine against hepatitis B need several doses to achieve protective immunization. In order to reduce the amount of repetitive injections, depot-based approaches represent a promising strategy. We pr...