Myeloid leukemic M1 cells that do not express p53 and transfected M1 clones that constitutively express the [Val135]p53 mutant or deregulated c-myc or coexpressing both genes grew autonomously in culture with a similar growth rate and cloning efficiency. Expression of deregulated c-myc in M1 leukemic cells enhanced susceptibility to induction of apoptotic cell death and resulted in a reduced le...

We consider the Multi-Area Economic Dispatch problem (MAEDP) in deregulated power system environment for practical multi-area cases with tie line constraints. Our objective is to generate allocation to the power generators in such a manner that the total fuel cost is minimized while all operating constraints are satisfied. This problem is NP-hard. In this paper, we propose Hybrid Particle Swarm...

Objective: A Modified Shuffled Frog Leaping (MSFL) algorithm based Multi-stage Fuzzy (MSF) PID controller is proposed in this paper to solve the Load Frequency Control (LFC) problem in a deregulated environment. The power system LFC problems are caused by small load perturbations which continuously disturb the normal operation of power system. The objectives of LFC are to minimize the transient...

Protein kinase D1 (PKD1) is a serine-threonine kinase that regulates various functions within the cell, including cell proliferation, apoptosis, adhesion, and cell motility. In normal cells, this protein plays key roles in multiple signaling pathways by relaying information from the extracellular environment and/or upstream kinases and converting them into a regulated intracellular response. Th...