Although, the drug delivery system (DDS) concept is not new, great progress has recently been made in the treatment of a variety of diseases. Targeting delivery of drugs to the diseased lesions is one of the most important aspects of DDS. To convey a sufficient dose of drug to the lesion, suitable carriers of drugs are needed. Nano and microparticle carriers have important potential application...

Abstract. A mathematical model of enzymes inhibition during microparticles formation has been developed. The model is based on radial substrate diffusion through diffusion layer that surrounds microparticle. The inhibition of enzymes was explained by enzyme adsorption on surface of the microparticles and substrate diffusion limitation through the diffusion layer. The diffusion module is depende...

background: recently, tissue engineering has developed approaches for repair and restoration of damaged skeletal system based on different scaffolds and cells. this study evaluated the ability of differentiated osteoblasts from adipose‑derived stem cells (adscs) seeded into hydroxyapatite/ tricalcium phosphate (ha‑tcp) to repair bone. methods: in this study, adscs of 6 canines were seeded in ha...

objective(s): sertoli cells support in vivo germ cell production; but, its exact mechanism has not been well understood. the present study was designed to analyze the effect of sertoli cells in differentiation of mouse embryonic stem cells (mescs) to germ cells.   materials and methods: a fusion construct composed of a stra8 gene promoter and the coding region of enhanced green fluorescence pro...

background: cell-based treatments are currently being actively received great attention among scientists and clinicians for a variety of diseases as well as diabetes .the aim of this study was to investigate the effect of allotransplantation of fetal liver-derived cell suspension in patients with type 1 diabetes. methods: patients with type 1 diabetes (n=16) aged 6-30 years-old were included in...

background: although cervical cancer mortality has reduced during last years, but it is still leading cause of mortality among women. many efforts have performed to develop new drugs and strategy to cure cervical cancer. mesenchymal stem cells (mscs) have many advantages that make them a suitable choice as a cell therapeutic agent in cancer treatment. there are different transfection methods fo...

conclusions this study shows that bdnf and ngf expression decreases in diabetic neuropathy. however, this decrease can be reversed through endurance training. these results also indicate that endurance training may have a potential role in compensating for neurotrophin deficiency following diabetic neuropathy. objectives this experimental study was designed and carried out at the tarbiat modare...

The practice of immunization of animals and humans has been carried out for centuries and is generally accepted as the most cost effective and sustainable method of infectious disease control. Over the past 20 years there have been significant changes in our ability to produce antigens by conventional extraction and purification, recombinant DNA and synthesis. However, many of these products ne...

By using theoretical analysis and molecular dynamics simulations, we investigate the structure of colloidal crystals formed by nonmagnetic microparticles (or magnetic holes) suspended in ferrofluids (called inverse ferrofluids), by taking into account the effect of polydispersity in size of the nonmagnetic microparticles. Such polydispersity often exists in real situations. We obtain an analyti...

For almost three decades Dr Jaime Gofin practiced and taught Community Oriented Primary Care (COPC) at the Hebrew University – Hadassah School of Public Health and Community Medicine in Jerusalem. Alone or sometimes with his wife and colleague, Dr Rosa Gofin, he has also been teaching COPC and the integration of medicine and public health in other parts of the world. This abridged, edited inter...