background: mesenchymal stem cells (msc) are a very promising transplantable stem cell source for a variety of cell replacement therapies. as the main source of msc is bone marrow (bm), most of studies have been done on bm-derived msc (bm-msc). umbilical cord (uc)-derived msc (uc-msc) which are recently introduced, is one of the good alternative source for these cells. the objective of this stu...

mesenchymal stem cells can be obtained from deferent tissues like adipose tissue, umbilical cord, placenta, skin, bone marrow, etc. these cells have regulatory effects on all types of immune cells such as dendritic cell, natural killers and lymphocytes. mesenchymal stem cells induce inhibitory phenotypes of antigen presenting cells (apcs) following their activity. they also change t cells pheno...

conclusions according to the results of the present study, it can be concluded that adipose derived mscs can be cultured in serum-free media with no change in their differentiating capacity. this finding gives us a hope for future cell therapy studies and trials with little concern about zoonotic infections or immunological reaction. results the isolated cells showed adherent spindle shaped mor...

background: mesenchymal stem cells (mscs) are undifferentiated cells that can differentiate and divide to other cell types. transplantation of these cells to the different organs is used for curing various diseases. objective: the aim of this research was whether mscs transplantation could treat the sterile testes. materials and methods: in this experimental study, donor mscs were isolated from...

BACKGROUND Mesenchymal stem cells (MSCs) are ideal candidates for treatment of diseases. Amniotic membranes are an inexpensive source of MSCs (AM-MSC) without any donor site morbidity in cell therapy. Adipose tissue derived stem cells (ASCs) are also suitable cells for cell therapy. There is discrepancy in CD271 expression among MSCs from different sources. In this study, the characteristics...

umbilical cord blood (ucb) has been used for transplantation in the treatment of hematologic disorders as a source of hematopoietic stem cells (hscs). because of insufficient number of cord blood cd34+ cells, the expansion of these cells seems to be important for clinical application. mesenchymal stromal cells (mscs), playing an important role in hscs maintenance, were used as feeder layer. apo...

objective(s):the application of stem cells holds great promises in cell transplants. considering the lack of optimal in vitro model for hepatogenic differentiation, this study was designed to examine the effects of laminin matrix on the improvement of in vitro differentiation of human bone marrow mesenchymal stem cells (hbm-msc) into the more functional hepatocyte-like cells. materials and meth...

hyaline cartilage is a vascular and neural tissue with scanty chondrocytes and limited regenerative ability. after some serious injuries of the cartilage, healing process will take place through the formation of fibrocartilage structures. currently, tissue engineering and cell therapy are 2 interesting therapeutic fields dealing with regenerative medicine. in this regard, tissue regeneration ha...

Background and Objectives: The mesenchymal stem cells derived from peripheral blood (PB) have been recognized as a promising source for allogeneic cell therapy. The aim of this study was to investigate the isolation, growth and differentiation ability of peripheral blood-isolated mesenchymal stem cells. Methods: The mononuclear cells were purified from fr...

BACKGROUND: Stem cell therapy in small animal medicineis still in its infancy and few in vitro and in vivo research projectsregarding animal Mesenchymal Stem Cells (MSCs) have beencarried out. On the other hand, Cell tracking is the first step of thecell-based therapies and is essential to recognize cell fate posttransplantation. OBJECTIVES: The aim of this study was toisolate, characterize, an...