background: the present study investigated the functional maturity of oligodendrocyte derived from rat bone marrow stromal cells (bmsc). methods: the bmsc were isolated from female sprague-dawley rats and evaluated for different markers, such as fibronectin, cd106, cd90, oct-4 and cd45. transdifferentiation of olc from bmsc was obtained by exposing the bmsc to dmso and 1 µm all-trans-retinoic a...

We previously demonstrated that human pericytes, which encircle capillaries and microvessels, give rise in culture to genuine mesenchymal stem cells (MSCs). This raised the question as to whether all MSC are derived from pericytes. Pericytes and other cells defined on differential expression of CD34, CD31, and CD146 were sorted from the stromal vascular fraction of human white adipose tissue. B...

Autologous stromal vascular fraction (SVF) can be enzymatically released from lipoaspirate obtained under local anesthesia. SVF is known to have regenerative, anti-inflammatory, pain mitigating, and immune-modulatory properties. Our translational research network has been studying the safety and efficacy of SVF since 2012. Almost 100 related physician teams around the world are applying the sam...

most common tumors of the spleen are hematologic and lymphoid malignancies. non-lymphoid and non-hematologic tumors of the spleen are very rare, the most common of which are vascular tumors. this group of tumors in the spleen is composed of heterogeneous tumors such as hemangioma, angioendothelioma (ae), littoral cell angioma, and angiosarcoma. there are several histologic forms of ae such as e...

INTRODUCTION Chronic migraines and tension-type headaches are debilitating diseases affecting 1.4 to 2.2% of the population with both quality of life and economic implications. To date, the pain associated with migraine and tension-type headaches has been controlled with a range of medications, with varying levels of success. In addition, the side-effect profile of these medications, as well as...

Abstract Background Novel therapeutic strategies for the healing of nonunion, which has serious effects on quality life patients, are needed. We evaluated effect local transplantation human stromal vascular fraction (SVF) cells fracture in a rat non-healing model and compared between freshly isolated (F) cryopreserved (C)-SVFs. Methods Non-healing was induced femur female immunodeficient rats (...