Zinc-responsive acral dermatitis is a rare entity characterized by chronic, persistent, well-defined, hyperpigmented, and hyperkeratotic plaques on the regions of body. One needs to differentiate this disease from its close differentials such as necrolytic migratory erythema pellagra. Herein, we report case zinc-responsive dermatosis in 35-year-old female previously treated with multiple topica...

In this clinical case, we attend to a patient with pigmented purpuric dermatosis, diagnosed Schamberg disease. It is the most frequent type of all dermatosis. benign, idiopathic, harmless skin condition, but its importance mainly due these characteristics. Good general practitioners should be able at least consider differential diagnosis whenever shows purpura. We update relevant information ab...

A three month old baby presented with refractory seizures, dermatosis and persistent metabolic acidosis. Biotinidase deficiency was diagnosed on enzyme assay. Patient responded dramatically to biotin supplementation.