Rheumatoid arthritis (RA) is characterised by the presence of an inflammatory synovitis accompanied by destruction of joint cartilage and bone. Destruction of cartilage matrix results predominantly from the action of connective tissue proteinases released by RA synovial tissues, chondrocytes, and pannus tissue. Several lines of evidence in RA and in animal models of arthritis support a role for...

Most cell junction proteins increase endothelial cell–cell adhesion. But junction adhesion molecule-C (JAM-C), despite its sticky name, loosens vascular endothelial cell connections, thus allowing increased blood vessel permeability. Increasing the permeability of small blood vessels is essential for new vessels to form and for leukocytes to escape the circulation and enter surrounding tissues ...

Background: Today, unfortunately, we are witnessing the expansion of competition in the world over the acquisition of weapons of mass destruction. Weapons of mass destruction are a set of weapons whose use causes widespread destruction and destruction of the environment and large-scale killing and massive human casualties, leaving no distinction between military and civilian and leaving irrepar...

Taking Renjiazhuang coal mine as the object of study, this paper carries on evaluation to destruction degree in this area by using extension theory and establishing evaluation extension model of land destruction in mining area. Results show that severe destruction area of collapse land in Renjiazhuang coal mine is 112.86hm, moderate destruction area is 372.27hm, light destruction area is 723.42...

Industries where prices decline rapidly experience early ‘shakeouts’. Existing models of the shakeout do not explain this negative relation between price decline and time to shakeout. We set up a vintage-capital model that explains this relation, and we provide some evidence in support of the mechanism that we propose. The relation emerges naturally in a vintage-capital model in which shakeouts...

teins interfere with apoptosis induced by the action of Fas ligand on immune cells, but no inhibitor of granzyme B activity was previously known. Andrade reported that the rate of binding of 100K to GrB was diffusionlimited, and that the proteins bound with high affinity. But cleavage occurred so slowly that the half-life of the complex averaged 3 hours. If a critical 100K aspartate was mutated...