HarvestPlus, part of the Consultative Group on Internation Agriculture research (CGIAR) Program on Agriculture for Nutrition and Health (A4NH) uses conventional plant breeding techniques to develop staple food crops that are rich in micronutrients, a food-based approach to reduce micronutrient malnutrition known as biofortification. The nutritional breeding targets are established based on the ...

Panthenol is the alcohol analogue of panthothenic acid, known as vitamin B5, which is required for the biosynthesis of coenzyme A in cells. This compound exists as two stereoisomers, D-pathenol and L-panthenol, only the former being biologically active (1). It is a common ingredient in pharmaceutical products, for example in topical treatments for rhinitis, conjunctivitis, sunburn, and wounds, ...

Purpose : to develop approaches differentiated substitution therapy in patients with dry eye (DE) of mild and moderate severity. Patients methods . We examined 86 DE (22–45 years old; 38 men, 48 women). Group-1 included 54 (54 eyes) under conditions combined lipid-mucose-deficiency, group-2 32 (32 against the background lipid-aqua-mucose-deficiency. Conducted: symptoms registration (OSDI scale)...

Introduction. In modern pharmacology, more and widely used molecular complexes (MC) based on donor-acceptor or, weaker, intermolecular interactions, to stabilize dosage forms in the composition of pharmaceutical substances or their targeted delivery. This trend is actively developing, because molecules forming MK, which has a certain spatial structure, are preserved can be released unchanged. T...

A case of dilated cardiomyopathy in a young boy secondary to type II 3-methylglutaconic aciduria is described. A metabolic cause for his dilated cardiomyopathy was suspected because of the development on the electrocardiogram of an unusual "camel's hump" shape of the T waves, and of progressive thickening with increasing echogenicity of the left ventricular wall. He initially improved on digoxi...

The production of 25-hydroxycholecalciferol (25(OH)D) in the liver is dependent on vitamin D obtained from the diet and from exposure to UV light. UV rays stimulate the conversion of provitamin D in the skin to vitamin D, making it available to the liver for hydroxylation to 25(OH)D. The circulating concentrations of 25(OH)D are considered to be reflective of the individual’s total vitamin D ex...

Burning and aching of the extremities are often found in certain nutritional disorders of the nervous system and in diabetic neuropathy ; these symptoms always dominate the clinical picture of a peripheral neuropathy known as the burning feet syndrome. An excellent description of this syndrome was given by Smith & Woodruff (195 I) who observed several cases in malnourished persons in Japanese p...

BACKGROUND The form of vitamin D (vitamin D3) in fortified milk and the provitamin D produced by the body undergo metabolic activation to a biologically active form, 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3]. This compound can induce cell differentiation and can prevent proliferation of cancer cells. However, because 1alpha,25(OH)2D3 is hypercalcemic (effective in increasing serum calciu...

Efforts are underway for development of crops with improved levels of provitamin A carotenoids to help combat dietary vitamin A deficiency. As a global staple crop with considerable variation in kernel carotenoid composition, maize (Zea mays L.) could have a widespread impact. We performed a genome-wide association study (GWAS) of quantified seed carotenoids across a panel of maize inbreds rang...