activity in liver homogenate from di-2-ethylhexyl phthalate (DEHP)-treated rats. Ohyama9) showed in vitro that PAEs inhibited mitochondrial respiration, with di-n-butyl phthalte (DBP) showing the strongest effect, and he concluded that PAEs were inhibitors of electron and energy transfer systems but not uncouplers. Takahashi10) also found inhibitory effects of PAEs on respiration in vitro and a...

People are constantly exposed to phthalates, due their common use in the production of plastics, pharmaceuticals, cosmetics and skin care products. The ability phthalates disrupt endocrine signaling, leading developmental, reproductive metabolic defects, has been studied, yet how interfere with these biological functions is still unclear. To uncover DBP interacting molecular pathways, we raised...

A method was developed to assess leaching of several poly(vinyl chloride) (PVC) plasticizers in aqueous media using gas chromatography (GC), and compared to a gravimetric standard test method (ASTM Method D1239). The GC method was a more direct measurement of plasticizer concentration in the aqueous phase. The leaching of commercial plasticizers, as well as several series of "green" candidate p...

Plastic waste has become a growing concern in terms of marine pollution, but little information is available on plastic debris and its possible risks chemical additives exposure the deep-sea. This study focused identification polymer type additive concentrations 21 collected from deep-sea Sagami Bay, Japan West Pacific Ocean under Kuroshio Extension recirculation gyre (KERG) zone (water depth: ...

BACKGROUND In addition to its well-established role in maintaining skeletal health, vitamin D has essential regulatory functions in female reproductive and pregnancy outcomes. Phthalates and bisphenol A (BPA) are endocrine disruptors, and previous research has suggested that these chemical agents may disrupt circulating levels of total 25(OH)D in adults. OBJECTIVES We investigated the relatio...

BACKGROUND Prior research reports inverse associations between maternal prenatal urinary phthalate metabolite concentrations and mental and motor development in preschoolers. No study evaluated whether these associations persist into school age. METHODS In a follow up of 328 inner-city mothers and their children, we measured prenatal urinary metabolites of di-n-butyl phthalate (DnBP), butylbe...

After briefly discussing human exposure to phthalates--diesters of 1,2-benzenedicarboxylic acid (phthalic acid)--this article first presents recent findings from the Study for Future Families, a multi-center pregnancy study in which the human analogue of the phthalate syndrome was first identified. This is one of an increasing number of studies that have investigated human endpoints in relation...

Phenotype results from interactions between genetics and environment, but for most environmental chemical exposures, such interactions are theoretical. The phenotypic response of the testis to in utero dibutyl phthalate (DBP) exposure was compared between two strains of Long-Evans (LE) rats, the orl substrain with inherited cryptorchidism and an outbred (wt) strain. orl and wt LE rats were expo...

Phthalate esters (PEs), especially di-n-butyl phthalate (DBP) and di-(2-ethylhexyl) phthalate (DEHP) were detected in various water samples such as river water, well water and tap water. On degradation tests of PEs, Tempaku River water degraded almost 100% of diethyl phthalate (DEP), di-isobutyl phthalate and DBP, and approximately 70% of DEHP. All eight isolates from Tempaku River water (R1-R7...