BACKGROUND Collagen cross linking (CXL) of the cornea has been developed recently as a new treatment for multidrug-resistant infectious keratitis. The aim of this study is to summarize the previously published data and evaluate the effectiveness of this treatment. RESULTS The search identified 12 articles. The number of eyes was 104. The infectious keratitis was associated with bacteria in 58...

BACKGROUND Corneal ulcers often lead to scarring and astigmatism, and significant loss of vision is a common consequence. OBJECTIVE To determine the rate of graft rejection, one of the most serious concerns with this procedure, and to evaluate the recovery of visual function in those patients for whom the operation was successful. METHODS We describe a retrospective study of 33 corneal ulce...

As hydration proceeded, the mosaic spread, or degree of misorientation, increased. This was apparent by the increasing lengths of the arcs emanating out from the h=1 and h=2 lamellar orders, shown in Fig. S1. Mosaic spread was determined by examining lamellar orders in the LAXS CCD position. Matlab was used to plot the intensity of a lamellar order as a function of η, the angle off the meridian...

PURPOSE To report surgical therapies for corneal perforations in a tertiary referral hospital. METHODS Thirty-one eyes of 31 patients (aged 62.4±18.3 years) with surgically treated corneal perforations from January 2002 to July 2013 were included in this study. Demographic data such as cause of corneal perforation, surgical procedures, and visual outcomes were retrospectively analyzed. RESU...

Dual leucine zipper kinase (DLK) promotes growth cone motility and must be restrained to ensure normal development. PHR (Pam/Highwire/RPM-1) ubiquitin ligases therefore target DLK for degradation unless axon injury occurs. Overall DLK levels decrease during development, but how DLK levels are regulated within a developing growth cone has not been examined. We analyzed the expression of the fly ...

Purpose. To evaluate effects of lamellar keratectomy and intrastromal injection of 0.2% fluconazole (LKIIF) on fungal keratitis. Methods. Data for 54 eyes of consecutive patients with fungal keratitis treated with LKIIF were retrospectively analyzed. The lesions in these eyes did not heal or were aggravated after antifungal chemotherapy for 7 days. The maximum lesion diameters were ≤5 mm and ma...

introduction: to compare the efficacy and cost-effectiveness of femtosecond laser versus mechanical microkeratome corneal flap creation in correction of refractive errors. methods: i this review, a comprehensive search of medline, scopus, cochrane, trip database, supplemented by hta and economic databases was performed. we searched for randomized controlled trials (rcts) of femtosecond laser wh...

Post-transplant diabetes is an untoward effect often observed under immunosuppressive therapy with cyclosporin A. Besides the development of peripheral insulin resistance and a decrease in insulin gene transcription, a beta-cell toxic effect has been described. However, its molecular mechanism remains unknown. In the present study, the effect of cyclosporin A and the dual leucine-zipper-bearing...