Traditional diffusion tensor imaging (DTI) maps brain structure by fitting a diffusion model to the magnitude of the electrical signal acquired in magnetic resonance imaging (MRI). Fractional DTI employs anomalous diffusion models to obtain a better fit to real MRI data, which can exhibit anomalous diffusion in both time and space. In this paper, we describe the challenge of developing and empl...

C. S. Gil, N. Colgan, A. J. Bakermans, B. J. van Nierop, G. J. Strijkers, H. C. van Assen, and K. M. Curran School of Medicine and Medical Sciences, University College of Dublin, Dublin, Belfield, Dublin 16, Ireland, Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, Biomedical Image Analysis, Department of Biomedical Engineering, E...

In this work, the effect of fluid-attenuated inversion recovery (FLAIR) on measured diffusion anisotropy was investigated in gray matter. DTI data were obtained with and without FLAIR in six normal volunteers. The application of FLAIR was experimentally demonstrated to lead to a consistent increase in fractional anisotropy (FA) in gray-matter regions, which was attributed to suppressed partial ...

An active area of research involves optimally modeling brain diffusion MRI data for various applications. In this study Bayesian analysis procedures were used to evaluate three models applied to phase-sensitive diffusion MRI data obtained from formalin-fixed perinatal primate brain tissue: conventional diffusion tensor imaging (DTI), a cumulant expansion, and a family of modified DTI expression...

Background and Aim: The methods for detecting brain activation with fMRI, MRI provides a way to measure the anatomical connections which enable lightning-fast communication among neurons that specialize in different kinds of brain functions. Diffusion tensor imaging is able to measure the direction of bundles of the axonal fibers which are all aligned. Besides mapping white matter fiber tracts,...

It is unknown whether dilated perivascular spaces can affect the adjacent neuronal fibers. We describe conventional MR and diffusion tensor imaging findings of a case with multiple, prominent dilated perivascular spaces in the left cerebral hemisphere. Diffusion tensor imaging showed no alterations in the fractional anisotropy and apparent diffusion coefficient values for the corona radiata, po...

During the past few years, The Journal of Neuroscience has published more than 30 articles that describe investigations that used Diffusion Tensor Imaging (DTI) and related techniques as a primary observation method. This illustrates a growing interest in DTI within the basic and clinical neuroscience communities. This article summarizes DTI methodology in terms that can be immediately understo...

In selected patients with medically refractory epilepsy, surgical treatment can render the patients seizure free or significantly reduce seizure frequency. Temporal lobe resection (TLR) for temporal lobe epilepsy (TLE) is the most commonly performed epilepsy surgery procedure. A visual field defect (VFD) due to injury to the optic radiation (OR) may occur after TLR. Diffusion tensor imaging (DT...

BACKGROUND Knowledge of the individual course of the optic radiations (ORs) is important to avoid postoperative visual deficits. Cadaveric studies of the visual pathways are limited because it has not been possible to separate the OR from neighboring tracts accurately and results may not apply to individual patients. Diffusion tensor imaging studies may be able to demonstrate the relationships ...