نتایج جستجو برای: dimethyl methylphosphonate

تعداد نتایج: 26528  

Journal: :Chemical communications 2011
Neil S Keddie Yulin Ye Tashfeen Aslam Tomas Luyten Davide Bello Clive Garnham Geert Bultynck Antony Galione Stuart J Conway

The syntheses of four D-myo-inositol 1,4,5-trisphosphate (InsP(3)) derivatives, incorporating phosphate bioisosteres at the 5-position, are reported. The methyl phosphate ester and sulfate derivatives retain InsP(3) receptor (InsP(3)R) agonist activity; the compounds that possess a methylphosphonate or a carboxymethyl moiety are InsP(3)R antagonists.

2010
Aashiq H. Kachroo Chien-Hui Ma Paul A. Rowley Anna D. Maciaszek Piotr Guga Makkuni Jayaram

Two conserved catalytic arginines, Arg-173 and Arg-292, of the tyrosine site-specific recombinase Cre are essential for the transesterification steps of strand cleavage and joining in native DNA substrates containing scissile phosphate groups. The active site tyrosine (Tyr-324) provides the nucleophile for the cleavage reaction, and forms a covalent 3'-phosphotyrosyl intermediate. The 5'-hydrox...

2015
Daniela del Valle David Karl Benedetto Barone Robert R. Bidigare Glenn S. Carter Matthew J. Church Rhea Foreman David M. Karl

Methylphosphonate (MPn) metabolism has been proposed to be an aerobic source of methane in surface oceanic waters. Previous work by Daniela del Valle, C-MORE post-doctoral fellow in the laboratory of Prof. David Karl, has shown that even though microbes are able produce methane from dissolved MPn in the ocean, this process is not a significant source of methane at Station ALOHA. However, this w...

Journal: :Chemical research in toxicology 2003
Karin T Lum Henry J Huebner Yingchun Li Timothy D Phillips Frank M Raushel

The toxicity for analogues of sarin (GB), soman (GD), and VX was evaluated using Hydra attenuata as a model organism. The organophosphate nerve agent analogue simulants used in this investigation included the following: isopropyl p-nitrophenyl methylphosphonate (for GB); pinacolyl p-nitrophenyl methylphosphonate (for GD); and diisopropyl S-(2-diisopropylaminoethyl)phosphorothioate, diethyl S-(2...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2015
Janice E Chambers Howard W Chambers Edward C Meek Kristen E Funck Manikanthan H Bhavaraju Steven R Gwaltney Ronald B Pringle

Paraoxonase 1 (PON1) is a calcium-dependent hydrolase associated with serum high-density lipoprotein particles. PON1 hydrolyzes some organophosphates (OPs), including some nerve agents, through nucleophilic attack of hydroxide ion (from water) in the active site. Most OPs are hydrolyzed inefficiently. This project seeks to identify nucleophiles that can enhance PON1-mediated OP degradation. A s...

Journal: :Dalton transactions 2017
Klára Melánová Ludvík Beneš Jan Svoboda Vítězslav Zima Milan Vlček Miroslava Trchová

Eight new barium methylphosphonates were prepared and described. In dependence on pH, either barium hydrogen methylphosphonates or barium methylphosphonates can be formed. In the case of barium methylphosphonates, BaCH3PO3·3H2O crystallizes from the solution at room temperature and BaCH3PO3·H2O at a temperature above 65 °C. On heating, these hydrates form two anhydrous barium methylphosphonates...

2006
Harry Wood Waldo E. Cohn

A methylphosphonate derivative of BrdUrd3 is an inhibitor of the cellular uptake of 5F[6-3H]dUnd and other nucleosides (19). BrdUnd-OPO2Me also produces a delayed inhibitory effect on the growth of culture cells (18). The preparation and chemical properties of BrdUrd-OPO2Me have been re ported (18); the methylphosphonate ester linkage is not attacked by the phosphomonoesterases (8). Membrane tr...

2017
Bemba Sidi Mohamed Christian Périgaud Christophe Mathé

The racemic synthesis of new carbocyclic nucleoside methylphosphonate analogues bearing purine bases (adenine and guanine) was accomplished using bio-sourced furfuryl alcohol derivatives. All compounds were prepared using a Mitsunobu coupling between the heterocyclic base and an appropriate carbocyclic precursor. After deprotection, the compounds were evaluated for their activity against a larg...

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