In the aggregate freight demand modeling literature, temporal assignment (annual to daily flows) is often oversimplified or neglected altogether. Unlike passenger flows, freight flows over the course of a year are not uniform and can vary significantly as the result of trade-offs between inventory and transportation cost management. We introduce the first temporal assignment model that explicit...

BACKGROUND Epithelial ovarian carcinoma is a deadly disease characterized by overt peritoneal metastasis. Individual cells and multicellular aggregates, or spheroids, seed these metastases, both commonly found in ascites. Mechanisms that foster spheroid attachment to the peritoneal tissues preceding formation of secondary lesions are largely unknown. METHODS Cell culture models of SKOV-3, OVC...

In this paper we illustrate how the traditional shift-share model may be readily expanded to analyse disaggregate data on various age-sex cohorts of the labour market. Further we show that such results can be misleading unless age-sex-specific labour-force changes are explicitly considered. We then analyze the performance of the Canadian regional labour markets as an example of the proposed pro...

Researchers in the social and behavioural sciences often ask questions regarding the time-linked associations between two or more constructs at multiple assessments across time. Although their questions typically involve an interest in making within-subject inferences, the most commonly used analytic approach does not disaggregate between-from within-subject variations, resulting in a mismatch ...

The Internet can be a tool for increasing access to education while also maintaining or improving the quality of students’ learning. But if information technology is "bolted onto" existing programs, instructional costs increase. Instead, higher education must learn to use technology to disaggregate and disintermediate some of its current instructional programs and to recombine the resulting com...

The structure of transportation networks and the patterns of accessibility they give rise to are an important determinant of land prices, and hence urban spatial structure. While there is ample evidence on the cross-sectional relationship between location and land value (usually measured from the value of improved property), there is much less evidence available on the changes in this relations...

The class of simplicial decomposition (SD) schemes have shown to provide efficient tools for nonlinear network flows. When applied to the traffic assignment problem, shortest route subproblems are solved in order to generate extreme points of the polyhedron of feasible flows, and, alternately, master problems are solved over the convex hull of the generated extreme points. We review the develop...

The class of simplicial decomposition (SD) schemes have shown to provide e cient tools for nonlinear network ows. When applied to the tra c assignment problem, shortest route subproblems are solved in order to generate extreme points of the polyhedron of feasible ows, and, alternately, master problems are solved over the convex hull of the generated extreme points. We review the development of ...