Allelic association provides a means to map disease genes that, in a dense map of polymorphic markers, has considerably higher resolution than linkage methods. We describe here a composite likelihood estimate of location for a disease gene against a high-resolution marker map by using allele frequencies at linked loci. Data may be family-based, as in the transmission disequilibrium test, or fro...

This paper presents the application of Exploratory Spatial Data Analysis (ESDA) and Kriging from GIS (ArcGIS8.3) in disease mapping through the analysis of hepatitis B in China. The research shows that geostatistical analysis techniques such as Kriging and ESDA have a good effect in disease mapping. Kriging methods can express properly the spatial correlation. Furthermore, unlike model-based me...

This paper is directed to the question of how to model and design an efficient tool for the intelligent mapping which is based on both dynamic and efficient storage of data and soft computing. The former is performed by our method that learns how to store, search and delete the data. After pointing out the limitation of the crisp evaluation of the distance between two points, we argue in favor ...

Vulvar cancer is a rare gynecological malignancy with mainly lymphatic spread. Sentinel node mapping plays an important role in the management of this gynecological malignancy. In the current study, we reported our experience in sentinel node mapping of vulvar cancer and review the literature accordingly. Since the introduction of sentinel node mapping to the surgical oncology community of our ...

BACKGROUND/AIMS Statistical analysis of age-at-onset involving family data is particularly complicated because there is a correlation pattern that needs to be modeled and also because there are measurements that are censored. In this paper, our main purpose was to evaluate the effect of genetic and shared family environmental factors on age-at-onset of three cardiovascular risk factors: hyperte...

Mapping disease transmission risk is crucial in public and animal health for evidence based decision-making. Ecology and epidemiology are highly related disciplines that may contribute to improvements in mapping disease, which can be used to answer health related questions. Ecological niche modeling is increasingly used for understanding the biogeography of diseases in plants, animals, and huma...