Patients with chronic granulomatous disease are predisposed to fungal infections and are therefore routinely prescribed antifungal prophylaxis. We report a case where acremonium was responsible for causing a cutaneous infection (mycetoma) despite antifungal prophylaxis. Treatment with voriconazole was initiated and the infection gradually resolved. This case highlights the need for careful clin...

Background: Cytomegalovirus (CMV) is one of the leading viral agents that can pave way for serious complications and organ damage in solid transplant (SOT) recipients after transplantation. Strategies have been developed to protect at-risk patients from CMV infection following Since more than 90% adults Turkey were positive IgG, universal prophylaxis was applied, results evaluated. Objectives: ...

how to cite this article:  fallah r, akhavan karbasi s, shajari a, fromandi m. the efficacy and safety of topiramate for prophylaxis of migraine in children. iran j child neurol. 2013 autumn; 7(4):7-11. objective migraine is the most common acute intermittent primary headache in children and prophylactic therapy is indicated in children with frequent or disabling headaches. the purpose of this ...

The allogeneic hematopoietic stem cell transplant (allo-HCT) represents an important therapeutic strategy for acute leukemias, lymphomas and solid neoplasms, also used in benign diseases, such as aplastic anemia inborn errors of immunity. This treatment requires myeloablative chemotherapy (conditioning regimen) followed by the infusion donor-derived cells. However, this procedure carries some r...

High incidence and mortality rate of pulmonary thromboembolism urge physicians to be aware of its occurrence and treatment. Pulmonary thromboembolism (PE) typically manifests itself with acute dyspnea and tachycardia and may occur along with deep vein thrombosis. However, syncope, chest pain and heart failure decompensation in previously stable patients might be another presenting signs and sym...

An observational, longitudinal and prospective study was carried out from October 2011 to March 2012 in order to evaluate the adequacy of thromboembolic prophylaxis prescribed in an Emergency Department according to the PRETEMED (Prevention of thromboembolic venous disease in medical patients) guide. For each patient an adjusted risk of venous thromboembolism (VTE) was calculated and the clinic...

STUDY OBJECTIVE Pneumocystis carinii pneumonia (PCP) is a major late complication of HIV infection associated with morbidity and mortality. Because chemoprophylaxis is highly effective, cases of PCP can be viewed as failures in the management of HIV disease. METHODS We reviewed demographic, clinical, and cost data for all cases of confirmed HIV-related PCP at The Johns Hopkins Hospital in 199...

Central nervous system (CNS) involvement is a serious complication of non-Hodgkin lymphoma (NHL), with an extremely poor outcome. In most cases, relapse in the CNS manifests as leptomeningeal disease. The relatively short interval between the initial diagnosis of NHL and CNS involvement implies that seeding of the cerebrospinal fluid occurs early in the natural history of the disease and sugges...

One of the main aims of venereal disease education is to encourage the use of prophylactic techniques by sexually-active persons. To do this educators must convey information about prophylaxis that is relevant. This study was designed to assess the knowledge, attitude, and behaviour regarding prophylaxis of a group of 200 American adolescent girls. The findings suggest areas of prophylaxis that...

Methods We designed a three phases prospective study of patients admitted to a general ICU of a tertiary university hospital. During first 4 months, weekly collection days are established, gathering demographic variables, reason for admission, severity scores, risk factors for hemorrhage and thrombosis as well as VTED prophylactic measures prescribed. Data were analyzed using a Failure Mode and...