Sepsis is associated with the activation of a number of host defence mechanisms that lead to profound metabolic changes. The haematological changes primarily involve leucocytes, platelets and the haemostasis system. The well-known leucocyte alterations entail neutrophilia or neutropenia which are directly related to the ongoing infection. These will not be discussed in this article. This review...

We report a 31-year-old female who had repeated thrombosis and was diagnosed as having congenital homozygous protein C deficiency based on decreased protein C antigen and activity, and the findings of family history. This patient had shown no symptom of thrombosis until the age of 27 years, when she had cerebral infarction as the first symptom. Low molecular weight heparin was useful for dissem...

The blood coagulation cascade is regulated by the luminal surface of the endothelial cell lining.1 Endothelial cells synthesize tissue factor pathway inhibitor (TFPI), which, in part, binds to the cell surface glycosaminoglycans and inhibits factors Xa, VIIa, and tissue factor.2 Endothelial cells also produce and exhibit thrombomodulin (TM) on their luminal surface.3 TM is a kind of thrombin re...

Disseminated intravascular coagulation (DIC) is a systemic activation of the system, which results in microvascular thrombosis and, simultaneously, potentially life-threatening haemorrhage attributed to consumption platelets and factors. Underlying conditions, e.g. infection, cancer, or obstetrical complications are responsible for initiation propagation DIC process. This review provides insigh...

Disseminated intravascular coagulation (DIC) is a complication of a variety of severe underlying diseases and a contributing factor in multi-organ failure and death. DIC is diagnosed on the basis of clinical findings (organ failure, bleeding) and laboratory abnormalities. The laboratory data include (repeated) measurements of platelet count and global clotting tests, to which more specific and ...

CONTEXT Cancer is a prothrombotic state and anticancer therapies are often complicated by vascular events. The risk of developing thromboembolic events is substantially increased in patients with pancreatic cancer. One possible presentation of vascular events in pancreatic cancer is disseminated intravascular coagulation (DIC). CASE REPORT In our case a patient with a diagnosis of pancreatic ...