In this work we have examined the requirements for activity of the acidic domain of Vmw65 (VP16) by deletion and site-directed mutagenesis of the region in the context of GAL4 fusion proteins. The results indicate that the present interpretation of what actually constitutes the activation domain is not correct. We demonstrate, using a promoter with one target site which is efficiently activated...

Type I (distal) renal tubular acidosis (RTA) is a disorder associated with the failure to excrete hydrogen ions from the distal renal tubule. It is characterized by hyperchloremic metabolic acidosis, an abnormal increase in urine pH, reduced urinary excretion of ammonium and bicarbonate ions, and mild deterioration in renal function. Hypercalciuria is common in distal RTA because of bone resorp...

Su W, Bush CR, Necela BM, Calcagno SR, Murray NR, Fields AP, Thompson EA. Differential expression, distribution, and function of PPARin the proximal and distal colon. Physiol Genomics 30: 342–353, 2007. First published May 22, 2007; doi:10.1152/physiolgenomics.00042.2007.—Suppression of colon carcinogenesis by peroxisome proliferator-activated receptor (PPAR)is likely due to some effect of PPAR...

    Background: Giant cell tumor (GCT) of the bone is a benign neoplasm with local aggressive behavior. Distal ulna is a very rare place for GCT. Published studies have mainly focused on case reports, and thus there is no consistent treatment strategy for this tumor at this location. This retrospective study was conducted to evaluate the oncological and functional results of 2 di...

We describe a new technique of pedicle freezing of the distal radius with malignant bone tumour and osteotomy of the normal ulna. The distal radius was sufficiently elevated to enable freezing without damaging adjacent tissues by releasing the distal radio-ulnar and radio-carpal joint and cutting the middle third of the ulna. The distal radius (including the tumour) was soaked in liquid nitroge...

Objective(s):   This study aimed to address the gold nanoparticle(GNP)-dose and exposure duration effect on the kidney function of rats: in vivo.   Materials and Methods: A total of 32 healthy male Wistar rats were used in this study. Animals were randomly divided into groups, three GNP-treated groups and control group. Group 1, 2 and 3 received. /5 cc of solution containing 5, 10,100 ppm Au vi...

In the desert of Abarkoh Basin, Central Iran, the influence of playa-lake level fluctuations on recent sedimentation mode of a terminal ephemeral fluvial-fan system and adjacent lacustrine/aeolian sediments of a playa fringe environment has been investigated. The surface geomorphology-sedimentology and its relationship with shallow subsurface sediments along a >25 km transect, has been studied....

Background: Distal radius fractures are one of the most common fractures of skeletal system and because of the aging of population, its incidence is rising. The aim of the present research was to evaluate the close reduction and percutaneous pin fixation as a treatment option. Material and methods: 44 patients who were type 2 according to universal classification or type 2 or 3 according to Ol...