The parametrically pumped Kerr model describes a driven-dissipative nonlinear cavity, whose nonequilibrium phase diagram features both continuous and discontinuous quantum transitions. We consider the consequences of these critical phenomena for fluctuations photocurrent obtained via weak measurements on cavity. Considering direct photodetection homodyne detection schemes, we find that current ...

In practice in finite-element stress analysis, the engineer first needs to know if key stresses are converging, and second if they have converged to a reasonable level of accuracy. Then these stresses can be reliably used in design. The engineer further needs to know if, instead, key stresses are diverging because of singularities present. Then these stresses can be of no direct use in design. ...

Mutations in the KCNQ2 gene, encoding for voltage-gated Kv7.2K(+) channel subunits, are responsible for early-onset epileptic diseases with widely-diverging phenotypic presentation, ranging from Benign Familial Neonatal Seizures (BFNS) to epileptic encephalopathy. In the present study, Kv7.2 BFNS-causing mutations (W344R, L351F, L351V, Y362C, and R553Q) have been investigated for their ability ...

Four-domain voltage-gated Ca2+ (Cav) channels play fundamental roles in the nervous system, but little is known about when or how their unique properties and cellular roles evolved. Of the three types of metazoan Cav channels, Cav1 (L-type), Cav2 (P/Q-, N- and R-type) and Cav3 (T-type), Cav3 channels are optimized for regulating cellular excitability because of their fast kinetics and low activ...