Abstract The efficient segregation of replicated genetic material is an essential step for cell division. Bacterial cells use several evolutionarily-distinct genome systems, the most common which type I Par system. It consists adapter protein, ParB, that binds to DNA cargo via interaction with parS sequence; and ATPase, ParA, nonspecific mediates transport. However, molecular details how this s...

Abstract The detection of intracellular nucleic acids is a fundamental mechanism host defense against infections. dysregulated acid sensing, however, major cause for number autoimmune diseases. In this study, we report that GTPase-activating protein SH3 domain-binding 1 (G3BP1) critical both DNA- and RNA-induced immune responses. We found in human mouse cells, the deletion G3BP1 led to dampened...

The DNA-templated bioorthogonal synthesis of macrocyclic gene modulators is illustrated in the cover picture accompanying Research Article (e202215245) by Jyotirmayee Dash and co-workers. DNA secondary structures present telomere oncogene promoter proximally orient bifunctional alkyne azide fragments, enabling bond formation copper-free azide–alkyne cycloaddition live cells. high-affinity bindi...

Nucleic acid-based biosensors for the detection of specific proteins combine typical programmability synthetic DNA systems with artificially controlled DNA-protein communication. The high-affinity interaction between a target protein and ligand, such as an aptamer sequence, or double stranded domain, small peptide, is paired nature-mimicking molecular mechanism allowing probing, processing, tra...

The present study was conducted in order to investigate the pharmacological activities of three heterobimetallic coordination compounds: [Cd(N-bishydeten)2][Ni(CN)4] (C1), [Cu2(N-bishydeten)2Co(CN)6].3H2O (C2), and K[Cd(N-bishydeten)Co(CN)6].1.5H2O (C3) (N-bishydeten = N,N-bis(2-hydroxyethyl)-ethylenediamine). This paper describes the ability of complexes to inhibit cell growth, cell migration ...

The present study was conducted in order to investigate the pharmacological activities of three heterobimetallic coordination compounds: [Cd(N-bishydeten)2][Ni(CN)4] (C1), [Cu2(N-bishydeten)2Co(CN)6].3H2O (C2), and K[Cd(N-bishydeten)Co(CN)6].1.5H2O (C3) (N-bishydeten = N,N-bis(2-hydroxyethyl)-ethylenediamine). This paper describes the ability of complexes to inhibit cell growth, cell migration ...

objective(s): β-thalassemia is one of the most common genetic disorders in the world. as one of the promising treatment strategies, fetal hemoglobin (hb f) can be induced. the present study was an attempt to reactivate the γ-globin gene by introducing a gene construct containing klf1 binding sites to the k562 cell line. materials and methods: a plasmid containing a 192 bp sequence with two repe...