PURPOSE To develop an in-house software program that is able to calculate and generate the biological dose distribution and biological dose volume histogram by physical dose conversion using the linear-quadratic-linear (LQL) model. MATERIAL AND METHODS The Isobio software was developed using MATLAB version 2014b to calculate and generate the biological dose distribution and biological dose vo...

Helical tomotherapy with its advanced method of intensity-modulated radiation therapy delivery has been used clinically for over 20 years. The standard delivery quality assurance procedure to measure the accuracy of delivered radiation dose from each treatment plan to a phantom is time-consuming. RadCalc®, a radiotherapy dose verification software, has released specifically for beta testing a m...

Intensity-modulated radiotherapy (IMRT) for complex sites such as tumors of the head and neck requires a level of accuracy in dose calculation beyond that currently used for conformal treatment planning. Recent advances in treatment planning systems have aimed to improve the dose calculation accuracy by improving the modeling of machine characteristics such as interleaf leakage, tongue and groo...

Telecobalt machine is one of the essential equipment needed in many cancer centers and still prominently used for the treatment of a variety of cancer cases in developing countries. This study aims to evaluate the impact of tissue heterogeneity corrections on 3D treatment planning system (Prowess). The human body contains a variety of tissues and cavities which vary widely in their physical and...

This work investigates the accuracy of skin dose calculations using the Eclipse treatment planning system. Skin dose was measured using micro-MOSFETs for a range of irradiation conditions (open fields, physical wedges, dynamic wedges, different SSDs) for 6MV and 10MV beams, and compared with the mean dose calculated to a 2mm thick "skin" structure for semi-cylindrical phantoms (representative o...

The dosimetric impact of orthopedic metal artifact reduction (O-MAR) on spine SBRT patients has not been comprehensively studied, particularly with spinal prostheses in high-dose gradient regions. Using both phantom and patient datasets, we investigated dosimetric effects of O-MAR in combination of various metal locations and dose calculation algorithms. A physical phantom, with and without a t...

Monte Carlo (MC) simulation is commonly considered to be the most accurate dose calculation method in radiotherapy. However, its efficiency still requires improvement for many routine clinical applications. In this paper, we present our recent progress toward the development of a graphics processing unit (GPU)-based MC dose calculation package, gDPM v2.0. It utilizes the parallel computation ab...

aims: the aim of the present work is (1) to evaluate dose calculation accuracy of two commonly used algorithms for 15 mv small photon fields in a medium encompassing heterogeneity and (2) compare these results with measured results obtained using gafchromic film ebt2. materials and methods: authors employed kailwood (pinus wallichiana) to mimic lung. briefly, seven kailwood plates, each measuri...

Introduction: Treatment planning is the most important part of treatment. One of the important entries into treatment planning systems is the beam dose distribution data which maybe typically measured or calculated in a long time. This study aimed at shortening the time of dose calculations using artificial neural network (ANN) and finding the best method of training t...

The purpose of this study was to evaluate the effect of dose calculation accuracy and the use of an intermediate dose calculation step during the optimization of intensity-modulated radiation therapy (IMRT) planning on the final plan quality for lung cancer patients. This study included replanning for 11 randomly selected free-breathing lung IMRT plans. The original plans were optimized using a...