INTRODUCTION Gold nanoparticles have been used as radiation dose enhancing materials in recent investigations. In the current study, dose enhancement effect of gold nanoparticles on tumor cells was evaluated using Monte Carlo (MC) simulation. METHODS We used MCNPX code for MC modeling in the current study. A water phantom and a tumor region with a size of 1×1×1 cm3 loaded with gold nanopartic...

ID: 18959 Title: Micro-Dosimetry Study of the Radiation Dose Enhancement at the Gold-Tissue Interface for Nanoparticle-Aided Radiation Therapy

Background and purposeBrain metastasis impacts greatly on patients’ quality of life survival. The phase I NANO-RAD trial assessed the safety maximum tolerated dose systemic administration a novel gadolinium-based nanoparticle, AGuIX, in combination with whole brain radiotherapy patients multiple metastases not suitable for stereotactic radiotherapy.Materials methodsPatients measurable received ...

Gold is an excellent absorber of X-rays. If tumours could be loaded with gold, this would lead to a higher dose to the cancerous tissue compared with the dose received by normal tissue during a radiotherapy treatment. Calculations indicate that this dose enhancement can be significant, even 200% or greater. In this paper, the physical and biological parameters affecting this enhancement are dis...

Abstract High-resolution electron microscopy is achievable only when a high dose employed, practice that may cause damage to the specimen and, in general, affects observation. This drawback sets some limitations on range of applications high-resolution microscopy. Our work proposes strategy, based machine learning, which enables significant improvement quality Scanning Transmission Electron Mic...