Purpose This study is intended to compare dose-volume parameters evaluated using different forward planning- optimization techniques, involving two applicator systems in intracavitary brachytherapy for cervical cancer. It looks for the best applicator-optimization combination to fulfill recommended dose-volume objectives in different high-dose-rate (HDR) fractionation schedules. Material and ...

• Different impact of electron beam irradiation on aliphatic and aromatic thermoplastic polyurethanes. Degradation, chain scission snd crosslinking depends dose temperature. ThFFF as an alternative approach for advanced analysis crosslinked polymer structures. The polyurethane material was studied both with approximately equal molar amount hard soft segments. Irradiation doses up to 300 kGy (ki...

Ionizing radiation to a cancer site has the ability to convert the irradiated tumor in an immunogenic hub. However, radiation is a complex modifier of the tumor microenvironment and, by itself, is seldom sufficient to induce a therapeutically significant anti-tumor immune response, since it can also activate immune suppressive pathways. While several combinations of local radiation and immunoth...

The repair capacity of mouse lung was determined at 3 months after a single i.p. injection of cyclophosphamide (Cy) at a maximally tolerated dose of 275 mg/kg. Mice were irradiated to the whole thorax only with 1, 2, 9, or 15 fractions of X-rays using doses/fraction ranging from 1.2 to 11 Gy. Breathing rate (breaths per minute), histology and pulmonary mortality were used to assess lung damage....

1. A gamma camera was used to monitor continuously the uptake of radiolabelled polymeric immunoglobulin A (pIgA) into the rat body after intravenous injection. Uptake into liver was fast but, since the peak of liver labelling occurred only after 9-15 min, it was not sufficiently rapid to constitute a pulse dose. A perfused, isolated rat liver system was therefore established which could be give...

the optimal fractionation schedule for radiotherapy of head and neck cancer has been controversial. the objective of this randomized trial was to test the efficacy of hyperfractionation vs. standard fractionation. patients with squamous cell carcinoma of head and neck organs were randomly assigned to receive radiotherapy delivered with a) standard fractionation at 2 gy/fraction/day, 5 days/week...