DCL1 is the ribonuclease that carries out miRNA biogenesis in plants. The enzyme has two tandem double stranded RNA binding domains (dsRBDs) in its C-terminus. Here we show that the first of these domains binds precursor RNA fragments when isolated and cooperates with the second domain in the recognition of substrate RNA. Remarkably, despite showing RNA binding activity, this domain is intrinsi...

We show that RecN protein is recruited to a defined DNA double strand break (DSB) in Bacillus subtilis cells at an early time point during repair. Because RecO and RecF are successively recruited to DSBs, it is now clear that dynamic DSB repair centers (RCs) exist in prokaryotes. RecA protein was also recruited to RCs and formed highly dynamic filamentous structures, which we term threads, acro...

In this article, dynamic modeling of double walled cylindrical functionally graded (FG) microshell is studied. Size effect of double walled cylindrical FG microshell are investigated using modified couple stress theory (MCST). Each layer of microshell is embedded in a viscoelastic medium. For the first time, in the present study, has been considered, FG length scale parameter in double walled c...

‎An  oriented perfect path double cover (OPPDC) of a‎ ‎graph $G$ is a collection of directed paths in the symmetric‎ ‎orientation $G_s$ of‎ ‎$G$ such that‎ ‎each arc‎ ‎of $G_s$ lies in exactly one of the paths and each‎ ‎vertex of $G$ appears just once as a beginning and just once as an‎ ‎end of a path‎. ‎Maxov{'a} and Ne{v{s}}et{v{r}}il (Discrete‎ ‎Math‎. ‎276 (2004) 287-294) conjectured that ...