The aim of this study was to establish a correlation between in vitro dissolution and in vivo absorption data of prepared immediate release Gemifloxacin tablets (Zagam) and compare with conventional tablets of Gemifloxacin (Factive). In vitro release data were obtained for test and reference tablets by using the USP apparatus II, 0.01N HCl of pH 2.0 at 50 rpm. A group of six healthy, male human...

To ensure that a drug product will meet standards for identity, strength and stability as specified in the United States Pharmacopedia and National Formulary (USP/NF), it needs to pass a number of tests such as the content uniformity test and dissolution test at various stages of the manufacturing process. The sponsors usually have in-house specification limits based on some lower bounds of the...

in this study, attempts were made to evaluate the effect of various acrylic acid based carbopols on the release profile of a beta-adrenoreceptor blocking drug, propranolol hcl, from matrix-type tablets invitro. for this purpose, tablets containing 160 mg of propranolol hcl along with various amounts of carbopols 934 (c934), 971 (c971), 974 (c974) and pemulen (pem) were prepared using the wet gr...

this paper reviews the use of texture analysis in studying the performance of hydrophilic matrices of highly soluble drugs and different types of excipients (i.e. water-soluble, water-insoluble and swellable, and water insoluble and non-swellable). tablets were prepared by direct compression, and their swelling and erosion in presence of these different excipients were assessed with the help of...

Purpose: To evaluate the usefulness of the flow-through cell apparatus for testing commercial vaginal tablets containing poorly water-soluble clotrimazole. Methods: The effect of experimental conditions (type of dissolution medium, flow rate and positioning of the tablet) on the dissolution profile of clotrimazole were examined and optimal parameters for conducting the experiments were determin...

In recent years, oral tobacco-derived nicotine (OTDN) pouches have emerged as a new tobacco product category. They are available in variety of flavors and do not contain cut or ground leaf. The on!® fall within this category OTDN products currently marketed seven (7) with five (5) different levels. Evaluation the release from these is valuable for assessment product-to-product comparisons. work...

Objective: Simvastatin is lipid lowering agent that reduces the risk of total mortality and morbidity. For such a sensitive medicine, the availability of un-control brands, local and multinational is a point of thought. The objective of this study was to provide a comparative assessment of dissolution profile of six different brands of Simvastatin by applying dissolution profile comparison appr...