نتایج جستجو برای: dqb

تعداد نتایج: 134  

2015
Joseph J. Sabatino Scott S. Zamvil

Although historically overshadowed by CD4 T cells, and more recently by B cells, a number of lines of evidence point toward a potentially vital role of CD8 T cells in multiple sclerosis (MS) pathogenesis. CD8 T cells outnumber CD4 in the parenchyma of MS lesions and are abundant at the leading edge in chronic active lesions. Some studies have detected increased frequencies of myelin-specific CD...

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Journal: :Transplantation 2008
Rene J Duquesnoy

During recent years, increasing evidence has accumulated that preformed antidonor human leukocyte antigen (HLA) class II antibodies represent significant risk factors for transplant dysfunction and failure (1– 6). Also, the posttransplant development of anticlass II antibodies is associated with a higher incidence of acute and chronic rejection (7–14). In this issue, the report by Issa et al. (...

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1997
SALIL D. PATEL ANDREW P. COPE MAURO CONGIA TEDDY T. CHEN EUGENE KIM LARS FUGGER DIANE WHERRETT GRETE SONDERSTRUP-MCDEVITT

Glutamic acid decarboxylase isoform 2 (GAD65; EC 4.1.1.15) has been identified as a key target autoantigen of insulin-dependent diabetes mellitus (IDDM). IDDM is genetically associated with the major histocompatibility complex (MHC), and particular alleles from the HLA-DQ and HLA-DR loci contribute to disease. Among DR4 subtypes, HLA-DRB1*0401, HLA-DRB1*0402, and HLADRB1*0405 alleles lend susce...

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Journal: :Trends in Genetics 2021

Genes of the human leukocyte antigen (HLA)-DR15 haplotype show a strong association with disease risk for multiple sclerosis (MS).Current genotyping tools failed to pinpoint second HLA-DR allele, DRB5*01:01, besides well-known DRB1*15:01 gene, despite their close 100% linkage disequilibrium (LD).Functional studies illustrate complex mechanisms how both DR15 alleles shape CD4+ T cell repertoire ...

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