The clinical expression of rheumatoid arthritis (RA) varies considerably among individual patients. Genetic variations in human leucocyte antigen (HLA) may influence clinical expression. We re-examined the association of HLA-DR with susceptibility to and clinical expression of RA using genomic tissue typing, since most studies were based on (less reliable) serological techniques. Seventy-eight ...

Response mode research shows that participants under a judgment response mode demonstrate more compensatory processing than participants under a choice mode. Research on affect and choice reveals that positive-affect participants display more noncompensatory examination of information than negative-affect participants. In the present study, participants viewed a film clip to induce positive or ...

Response mode research shows that participants under a judgment response mode demonstrate more compensatory processing than participants under a choice mode. Research on affect and choice reveals that positive-affect participants display more noncompensatory examination of information than negative-affect participants. In the present study, participants viewed a film clip to induce positive or ...

DR. KILBURN: If I have heard correctly, Doctors Gareth Green and Sanford have drawn opposite conclusions. Although patients seem to have bronchitis and/or emphysema, they often die of bacterial overgrowth of the lung which has been called gram-negative pneumonia. This may have to be looked at as a highly important disease because it causes death, although it is not the original disease. Dr. Gre...

BACKGROUND Drug-resistant tuberculosis (DR-TB) is a major public health problem caused by various factors. It is essential to systematically investigate the epidemiological and, in particular, the ecological factors of DR-TB for its prevention and control. Studies of the ecological factors can provide information on etiology, and assist in the effective prevention and control of disease. So it ...

impressive. Spain, Italy, France, Germany, and Sweden all lost reigning monarchs, in the days when monarchs really reigned, to the disease. Dr Hopkins has not been satisfied with tracing the European history or even the Western history of the disease; he takes in the Asian dimension, and the African one, and details the effects of smallpox on the ruling houses of China and Japan, and among the ...

Many have argued that anthropology, as a four-field discipline, lacks intellectual coherence. Recent developments in the field of biotechnology and the possibility of producing chimeras with recognizable human characteristics make it necessary to think in terms of a new kind of “old” four-field holism. The production of a human/nonhuman chimera raises theoretical questions about the nature of t...

I read the commentary1 on ‘Abortion law: campaign groups and the quest for change’ in the October 2006 issue of the Journal with interest. In general, it provides a very balanced overview of the different groups seeking change in UK abortion legislation, summarising the concerns of both pro-life and pro-choice organisations. However, in his discussion and conclusions, Dr Vincent Argent ceases t...

Abstract Electric vehicles (EVs) are expected to provide substantial potential for demand response (DR) and, thus, the integration of renewable electricity sources in future energy system. However, DR can also have noticeable negative consequences, so-called avalanche effects. We systematically assess under which circumstances effects occur and what impact they on system cost savings EV owners....