In vivo cocktail pathway phenotyping (ICPP) is routinely used to assess the metabolic drug-drug interaction (mDDI) potential of new drug candidates (NDC) during drug development. However, there are a number of potential limitations to this approach and the use of validated drug cocktails and study protocols is essential. Typically ICPP mDDI studies assess only the impact of interactions followi...

For a partially degradable (PD) channel, the channel output state can be used to simulate the degraded environment state. The quantum capacity of a PD channel has been proven to be additive. Here, we show that the private classical capacity of arbitrary dimensional PD channels is equal to the quantum capacity of the channel and also single-letterizes. We prove that higher rates of private class...

A channel capacity is non-convex if the capacity of a mixture of different quantum channels exceeds the mixture of the individual capacities. This implies that there is a concrete communication scenario in which a sender can increase the transmission rate by forgetting which channel acts on the channel input. Previously, this surprising property had only been shown for the quantum capacity. Her...

This article argues that, properly analysed, the common law and the European Convention on Human Rights (ECHR) march hand in hand with the provisions of the Mental Capacity Act 2005 (MCA 2005) so as to impose a set of requirements on litigation friends acting for the subject of applications of proceedings before the Court of Protection ('P') which are very different to those currently understoo...

We examine the effect of a Danish reform in 2002 that increased compensation for permanent loss of earnings capacity and extended the period when whiplash claimants could get compensation for temporary loss of earnings. The first is subject to extensive state verification by the government while the second is not. Using weekly data about disability, drug purchases and use of health services dur...

berberine was loaded in yeast cells of saccharomyces cerevisiaeas a novel pharmaceutical carrier to improve the treatment ofmany diseases. the yeast-encapsulated active materialsshowedhigh stability and bioavailability due to the enhanced solubility and sustained releasing. in this study, different characteristics of prepared berberine loaded yeast cells (loading capacity, release kinetic order...

background: adverse cutaneous drug reactions (acdrs) are the most commonly reported adverse drug events. the causative drugs and clinical patterns of acdrs are different in various populations. this study was conducted to identify the clinical patterns, causative drugs and reasons for drug administration in patients hospitalized due to acdr. materials and methods: this retrospective study was c...

Although current therapies have improved leukemia survival rates, adverse drug effects and relapse are frequent. Encapsulation of edelfosine (ET) in lipid nanoparticles (LNs) improves its oral bioavailability and decreases its toxicity. Here we evaluated the efficacy of ET-LN in myeloid leukemia cell lines. Drug-loaded LN were as effective as free ET in sensitive leukemia cell lines. Moreover, ...

introduction: a growing number of muslim athletes now engage in international competition. this raises the question of the advice they should be given if a major event occurs during the month of ramadan. methods: a narrative review has been based upon books and extensive reviews completed by the author and other investigators. results: practical considerations hamper assessment of the effects o...