نتایج جستجو برای: drug resistancsequence homology
تعداد نتایج: 635775 فیلتر نتایج به سال:
Abstract Serial homology, i.e., homology between repetitive structures in the same individual organism, is a debated concept evolutionary developmental biology. The central question interpretation of “sameness” context body. This essay provides synthetic analysis main issues involved debate, connecting conceptual problems with current experimental research. It argued that serial not all-or-noth...
The high prevalence of brain disorders and the lack of their efficient treatments necessitate improved in-vivo pre-clinical models and tests. The zebrafish (Danio rerio), a vertebrate species with high genetic and physiological homology to humans, is an excellent organism for innovative central nervous system (CNS) drug discovery and small molecule screening. Here, we outline new strategies for...
There is an urgent need for the development of new drugs to treat Chagas' disease, which is caused by the protozoan parasite Trypanosoma cruzi. The enzyme dihydrofolate reductase (DHFR) has been a very successful drug target in a number of diseases and we decided to investigate it as a potential drug target for Chagas' disease. A homology model of the enzyme was used to search the Cambridge Str...
The ASO field is an emerging area of drug development that targets the disease source at RNA level, offering a promising alternative to therapies targeting downstream processes. SpliSense developing SPL84, inhaled for treatment CF patients carrying 3849 +10 kb C->T mutation. In order move into clinic, we performed full battery preclinical safety and toxicology studies with SPL84. vitro in silic...
The mutations present in the spike protein of omicron, a new variant SARS CoV2 favours high transmission Covid fection. To control rate infection finding an effective alternative drug can be beneficial. In our work, we have repurposed 1930 FDA approved drugs which best top five lead compounds based on their GOLD score are Telotris tetethyl, Oxyglutatione, Pentamidinium, Clindamycin palmitate, P...
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