background: tuberculosis (tb) is a major worldwide public health problem. the incidence of tuberculosis has decreased in iran in recent years. however, despite this dramatic decline, tuberculosis is still considered to be a major health problem in iran. objectives: the aim of this study was to investigate the epidemiological situation and main characteristics of tuberculosis in iran. patients a...

Tuberculosis remains one of the causes death from a single infectious bacterium. The inappropriate use antibiotics and patients’ non-compliance among other factors drive emergence drug-resistant tuberculosis. Multidrug-resistant extensively strains tuberculosis pose significant challenges to current treatment regimens, as their reduced efficacy against these limits successful patient outcomes. ...

Bacterial factors may contribute to the global emergence and spread of drug-resistant tuberculosis (TB). Only a few studies have reported on the interactions between different bacterial factors. We studied drug-resistant Mycobacterium tuberculosis isolates from a nationwide study conducted from 2000 to 2008 in Switzerland. We determined quantitative drug resistance levels of first-line drugs by...

Tuberculosis is an infectious disease caused by the germ Mycobacterium tuberculosis. The group of bacteria in addition to tuberculosis that can cause disorders airways known as MOTT (Mycobacterium Other Than Tuberculosis), which sometimes interfere with enforcement TB diagnosis and treatment. (TB) a high burden for Indonesia, not only because itself, but also its resistant several first-line dr...

OBJECTIVES To estimate the resistance rate and to correlate the clinical characteristics of resistant tuberculosis with the patients of pulmonary tuberculosis who were referred to the university hospital. METHODS We prospectively performed sensitivity tests for all patients who were diagnosed as active tuberculosis by sputum smear or sputum culture from January, 1995 to June, 1996. Patients p...

Tuberculosis remains a major global medical challenge and concern. In the world's population of over 7.4 billion people, 8.6 million are estimated to be infected with Mycobacterium tuberculosis; another 2.2 billion have latent tuberculosis. There is an annual incidence of 16,000 new cases in the USA and 7-8 million new cases worldwide, of which 440,000 are multidrug-resistant or extensively mul...

The emergence of the global threat of extensively drug-resistant (XDR) Mycobacterium tuberculosis reveals weaknesses in tuberculosis management and diagnostic services. We report the draft genome sequence of the first extensively drug-resistant Mycobacterium tuberculosis strain isolated in Malaysia. The sequence was also compared against a reference strain to elucidate the polymorphism that is ...

Non-tuberculous Mycobacteria (NTM) are emerging as an important opportunistic pathogen. Since clinical presentation of NTM infection is similar to tuberculosis (TB), patients present suspected TB or drug resistant TB. Presently in the National Tuberculosis Elimination Programme (NTEP ) not being speciated, but there urgent need characterize so that appropriate treatment can be given many specie...

Tuberculosis as a social human disease has been known since ancient times. Morbidity and mortality from multidrug-resistant TB (MDR-TB) extensively drug-resistant (XDR-TB) both in RS(Y) the Russian Federation remain high. In recent years, studies have conducted on effectiveness of chemotherapy using drug bedaquiline. State Budgetary Institution Republic Sakha (Yakutia) SPC “Phthisiology”, presc...

Drug resistance in tuberculosis predominantly, mono-resistance, multi drug resistance, extensively drug resistance and totally drug resistance have emerged as a major problem in the chemotherapy of tuberculosis. Failures of first and second line anti-tuberculosis drugs treatment leads to emergence of resistant Mycobacterium tuberculosis. Few genes are reported as the principal targets of the re...