English. This is particularly so in the early part of the book. When making a proposal, they often examine several possibilities which are all plausible in their framework. This should be welcomed by readers with only limited exposure to formal semantics. The authors address methodological issues at several points, since their main concern is the presentation of a fragment. Nevertheless, it wou...

A cross-sectional study was conducted to analyze the utilization of antidiabetic agents among patients with Type-2 Diabetes Mellitus in primary care clinics a South Indian rural province Erode district, Tamilnadu, India. The for period one year using structured validated questionnaire. There total 487 diabetic residing area south state were included this drug evaluation. Majority i

OBJECTIVES Both caspofungin and voriconazole were initially approved by the FDA with very narrow indications. Our aim was to evaluate the utilization patterns and comparative effectiveness of these agents early after marketing before any labeling change occurred. METHODS This was a retrospective cohort study utilizing a large healthcare database in the United States. Patients who received at ...

Compliance with malaria chemoprophylaxis programmes was studied in the National Railways and two large commercial farm labour forces in Zimbabwe. Prophylaxis was primarily conducted using pyrimethamine/dapsone and the study measured compliance rates through interview and the detection of drug in the urine. Compliance rates as indicated from registers or questioning were not always reliable and ...

The utilization of mathematical modeling and simulation in drug development encompasses multiple mathematical techniques and the location of a drug candidate in the development pipeline. Historically speaking they have been used to analyze experimental data (i.e., Hill equation) and clarify the involved physical and chemical processes (i.e., Fick laws and drug molecule diffusion). In recent yea...

The first Medicines Utilization Research in Africa group workshop and symposium brought researchers together from across Africa to improve their knowledge on drug utilization methodologies as well as exchange ideas. As a result, progress was made on drug utilization research and formulating future strategies to enhance the rational use of medicines in Africa. Anti-infectives were the principal ...

OBJECTIVES To evaluate the impact of retrospective drug utilization review (RDUR), pharmacist's interventions on physician prescribing, and the level of spillover effect on future prescriptions following the intervention. METHODS A retrospective case-control study was conducted at a pharmacy benefits management company using the available prescription data from April 2004 to August 2005. RDUR...

Drug utilization in the inpatient setting can provide a mechanism to assess drug prescribing trends, efficiency, and cost-effectiveness of hospital formularies and examine subpopulations for which prescribing habits may be different. Such data can be used to correlate trends with time-dependent or seasonal changes in clinical event rates or the introduction of new pharmaceuticals. It is now pos...

Overall drug overuse, including psychotropic, is the Croatian reality. Therefore, in between 2000 and 2012, the interventions to control drug overspending were undertaken. The main aims of the study are: to determine the morbidity trends of mental disorders registered in family medicine (FM), the trends in psychotropic drug utilization and to identify whether the trends of utilization have any ...

The application of appropriate rules for drug-drug interactions (DDIs) could substantially reduce the number of adverse drug events. However, current implementations of such rules in tertiary hospitals are problematic as physicians are receiving too many alerts, causing high override rates and alert fatigue. We investigated the potential impact of Korean national DDI rules in a drug utilization...