A 24 year old man developed severe asthma two years after starting to work in a plywood plant. Four years later the patient had to stop working because of the increasing severity of his asthma. Three months after leaving his job, the patient's asthma was greatly improved. His job consisted of placing plywood sheets into a drying machine. The plywood sheets had stayed outside in wet conditions f...

The inhalation route has many advantages in the treatment of diseases of the respiratory tract. Medication may be delivered directly to its site of action, giving a faster onset and allowing smaller doses of drug to be administered. Systemic absorption of the drug is diminished, reducing systemic side eVects. The drug treatment regimen for the vast majority of patients with asthma is straightfo...

This study investigates (1) the effect of modifying the design of a dry powder inhaler on the device performance, and (2) which design features significantly contribute to overall inhaler performance. Computational Fluid Dynamics (CFD) analysis was performed to determine how the flowfield generated in an Aerolizer at 60 l min(-1) varied when the inhaler grid and mouthpiece were modified. The co...

One of the advantages of dry influenza vaccines over conventional liquid influenza vaccines is that they can be used for alternative routes of administration. Previous studies showed that spray freeze-drying is an excellent technique to prepare vaccine containing powders for pulmonary delivery (J.P. Amorij, V. Saluja, A.H. Petersen, W.L.J. Hinrichs, A. Huckriede, H.W. Frijlink, Pulmonary delive...

Correct inhalation technique is essential for effective use of dry powder inhalers (DPIs), as their effectiveness largely depends on the patient’s inhalation manoeuvre. Children are an especially challenging target population for DPI development due to the large variability in understanding and inspiratory capacities. We previously performed a study in which we determined the prerequisites for ...

The inhalation route has many advantages in the treatment of diseases of the respiratory tract. Medication may be delivered directly to its site of action, giving a faster onset and allowing smaller doses of drug to be administered. Systemic absorption of the drug is diminished, reducing systemic side eVects. The drug treatment regimen for the vast majority of patients with asthma is straightfo...

The inhalation route has many advantages in the treatment of diseases of the respiratory tract. Medication may be delivered directly to its site of action, giving a faster onset and allowing smaller doses of drug to be administered. Systemic absorption of the drug is diminished, reducing systemic side eVects. The drug treatment regimen for the vast majority of patients with asthma is straightfo...

BACKGROUND Dry powder inhalers (DPIs) are inspiratory flow driven and hence flow dependent. Most patients with chronic obstructive pulmonary disease (COPD) are elderly and have poor lung function. The factors affecting their inspiratory flows through inhalers are unclear. OBJECTIVE To study peak inspiratory flows (PIFs) and their determinants through a DPI in COPD patients of varying age and ...

The inhalation route has many advantages in the treatment of diseases of the respiratory tract. Medication may be delivered directly to its site of action, giving a faster onset and allowing smaller doses of drug to be administered. Systemic absorption of the drug is diminished, reducing systemic side eVects. The drug treatment regimen for the vast majority of patients with asthma is straightfo...

The inhalation route has many advantages in the treatment of diseases of the respiratory tract. Medication may be delivered directly to its site of action, giving a faster onset and allowing smaller doses of drug to be administered. Systemic absorption of the drug is diminished, reducing systemic side eVects. The drug treatment regimen for the vast majority of patients with asthma is straightfo...