This paper presents the development of new functionality for the open-source rsync utility aimed at producing an efficient, scalable solution for multiple-site file synchronization. The context of our work is the Internet2 Distributed Storage Infrastructure (I2-DSI) project, which is developing a reliable, scalable, high performance storage service infrastructure for advanced applications in re...

The Campbell–Stokes sunshine recorder (CSSR) has been one of the most commonly used instruments for measuring sunshine duration (SD) through the burn length of a given CSSR card. Many authors have used SD to obtain information about cloudiness and solar radiation (by using Ångström–Prescott type formulas), but the burn width has not been used systematically. In principle, the burn width increas...

BACKGROUND Symptom burden in chronic kidney disease (CKD) is poorly understood. To date, the majority of research focuses on single symptoms and there is a lack of suitable multidimensional symptom measures. The purpose of this study was to modify, translate, cross-culturally adapt and psychometrically analyse the Dialysis Symptom Index (DSI). METHODS The study methods involved four phases: m...

Target audience Scientists and clinicians interested in Diffusion Spectrum MRI and its methodological development Purpose To demonstrate that Diffusion Spectrum Imaging at longer diffusion times gives rise to higher anisotropy measures, as illustrated by using a stimulated echo sequence in a clinical scanner in vivo. Diffusion Spectrum MRI (DSI) [1] has become a powerful tool for non-invasive i...

Inhibitory neurons in the thalamic reticular nucleus (TRN) play a critical role in controlling information transfer between thalamus and neocortex. GABAergic synapses formed by TRN neurons contact both thalamic relay cells and neurons within TRN. These two types of synapses are thought to have distinct roles for the generation of thalamic network activity, but their selective regulation is poor...

Combat exposures to blast can result in both peripheral damage to the ears and eyes and central damage to the auditory and visual processing areas in the brain. The functional effects of the latter include visual, auditory, and cognitive processing difficulties that manifest as deficits in attention, memory, and problem solving--symptoms similar to those seen in individuals with visual and audi...

Purpose: To measure the preferences and values of men newly diagnosed with prostate cancer (PC) using a web-based decision support technology—the Decision Support Intervention-Prostate Cancer (DSI-PC). Methods: Health information seeking behaviour, factors having an influence on the treatment decision, decision control, and preferred treatment were recorded by the DSI-PC program prior to the tr...

Background Colposcopy is subjective and management of young patients with high-grade disease is challenging, as treatments may impair subsequent pregnancies and adversely affect obstetric outcomes. Conservative management of selected patients is becoming more popular amongst clinicians; however it requires accurate assessment and documentation. Novel adjunctive technologies for colposcopy could...

The endocannabinoid 2-arachidonoylglycerol (2-AG) mediates retrograde synaptic depression including depolarization-induced suppression of excitation (DSE) and inhibition (DSI). 2-AG is degraded primarily by monoacylglycerol lipase (MAGL), which is expressed in neurons and astrocytes. Using knockout mice in which MAGL is deleted globally or selectively in neurons or astrocytes, we investigated t...