Luminescent lanthanide complexes consisting of a lanthanide-binding chelate and organic-based antenna molecule have unusual emission properties, including millisecond excited state lifetimes and sharply spiked spectra, compared to standard organic fluorophores. We have previously used carbostyril (cs124, 7-amino-4-methyl-2(1H)-quinolinone) as an antenna molecule (Li and Selvin, J. Am. Chem. Soc...

OBJECTIVES The objectives of the study were to assess the imaging features of hypovascular borderline lesions containing hypervascular foci on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) and to evaluate the ability of Gd-EOB-DTPA-enhanced MRI to diagnose high-risk borderline lesions possibly consistent with early hepatocell...

Aqueous complexation of Th(IV), U(IV), Np(IV), Pu(III/IV), and Ce(III/IV) with DTPA was studied by potentiometry, absorption spectrophotometry, and cyclic voltammetry at 1 M ionic strength and 25 °C. The stability constants for the 1:1 complex of each trivalent and tetravalent metal were calculated. From the potentiometric data, we report stability constant values for Ce(III)DTPA, Ce(III)HDTPA,...

OBJECTIVES To examine the contents of intraosseous cysts in patients with rheumatoid arthritis (RA) through the signal intensity characteristics on gadolinium-DTPA (Gd-DTPA) enhanced magnetic resonance imaging. METHODS The hand or foot joints of nine patients with the cystic form of RA (where the initial radiological abnormality consisted of intraosseous cysts without erosions) were imaged be...

BACKGROUND Previous studies have postulated an association between dentate nucleus T1 hyperintensity and multiple sclerosis (MS)-related progressive neurodegeneration. Therefore, MS patients have been excluded from most studies investigating brain deposition of gadolinium-based contrast agents (GBCAs). OBJECTIVE To study the hypothesis that dentate nucleus T1 hyperintensity in MS patients is ...

Introduction: A promising myeloperoxidase-sensing MRI agent, bis-5-hydroxytryptamide-diethylenetriamine-pentaacetate gadolinium [bis5HT-DTPA(Gd)] has been recently used for magnetic resonance imaging of in vivo myeloperoxidase (MPO) activity. In the presence of MPO, bis-5HT-DTPA(Gd) can be radicalized to form oligomers and bind to matrix proteins, resulting in increased spin-lattice relaxation ...

Fingerlings (0.23 g) and juveniles (267.04 of African catfish (Clarias gariepinus) were reared for 32 days under experimental aquarium conditions exposed to either 0.75 mg/L or 3.0 diethylenetriaminepentaacetic acid-iron(II) (Fe-DTPA) 12.0 Fe-DTPA in the water, respectively. These treatment groups compared a control group without additional Fe-DTPA. The growth, mortality, ethological indicators...

PURPOSE To evaluate the utility of Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) in characterizing atypically enhanced cirrhotic nodules detected on conventional Gd-DTPA-enhanced MR images. MATERIALS AND METHODS We enrolled 61 consecutive patients with 88 atypical nodules seen on conventional Gd-DTPA-enhanced MR images who underwent Gd-EOB-DTPA-enhanced MRI within a 3-month period. Us...

OBJECTIVES The main goal was to gain insights into the pharmacokinetics of intrapericardial drug delivery using magnetic resonance (MR) imaging analysis and the extracellular MR contrast agent gadopentetate dimeglumine (Gd-DTPA) as a model. BACKGROUND Recent development of catheter-based techniques to access the intact pericardial space has increased interest in intrapericardial delivery for ...

Stable gadolinium(III) chelates are nowadays routinely used as contrast agents for magnetic resonance imaging (MRI). Their non-covalent binding to human serum albumin (HSA) has shown to improve their efficacy. Non-covalent interactions lead to complex formation that can be quantified by several techniques that are mostly tedious and time-consuming. In this study, electrospray ionization mass sp...