OBJECTIVES To examine the contents of intraosseous cysts in patients with rheumatoid arthritis (RA) through the signal intensity characteristics on gadolinium-DTPA (Gd-DTPA) enhanced magnetic resonance imaging. METHODS The hand or foot joints of nine patients with the cystic form of RA (where the initial radiological abnormality consisted of intraosseous cysts without erosions) were imaged be...

BACKGROUND Previous studies have postulated an association between dentate nucleus T1 hyperintensity and multiple sclerosis (MS)-related progressive neurodegeneration. Therefore, MS patients have been excluded from most studies investigating brain deposition of gadolinium-based contrast agents (GBCAs). OBJECTIVE To study the hypothesis that dentate nucleus T1 hyperintensity in MS patients is ...

Introduction: A promising myeloperoxidase-sensing MRI agent, bis-5-hydroxytryptamide-diethylenetriamine-pentaacetate gadolinium [bis5HT-DTPA(Gd)] has been recently used for magnetic resonance imaging of in vivo myeloperoxidase (MPO) activity. In the presence of MPO, bis-5HT-DTPA(Gd) can be radicalized to form oligomers and bind to matrix proteins, resulting in increased spin-lattice relaxation ...

Fingerlings (0.23 g) and juveniles (267.04 of African catfish (Clarias gariepinus) were reared for 32 days under experimental aquarium conditions exposed to either 0.75 mg/L or 3.0 diethylenetriaminepentaacetic acid-iron(II) (Fe-DTPA) 12.0 Fe-DTPA in the water, respectively. These treatment groups compared a control group without additional Fe-DTPA. The growth, mortality, ethological indicators...

PURPOSE To evaluate the utility of Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) in characterizing atypically enhanced cirrhotic nodules detected on conventional Gd-DTPA-enhanced MR images. MATERIALS AND METHODS We enrolled 61 consecutive patients with 88 atypical nodules seen on conventional Gd-DTPA-enhanced MR images who underwent Gd-EOB-DTPA-enhanced MRI within a 3-month period. Us...

OBJECTIVES The main goal was to gain insights into the pharmacokinetics of intrapericardial drug delivery using magnetic resonance (MR) imaging analysis and the extracellular MR contrast agent gadopentetate dimeglumine (Gd-DTPA) as a model. BACKGROUND Recent development of catheter-based techniques to access the intact pericardial space has increased interest in intrapericardial delivery for ...

Stable gadolinium(III) chelates are nowadays routinely used as contrast agents for magnetic resonance imaging (MRI). Their non-covalent binding to human serum albumin (HSA) has shown to improve their efficacy. Non-covalent interactions lead to complex formation that can be quantified by several techniques that are mostly tedious and time-consuming. In this study, electrospray ionization mass sp...

OBJECTIVE The aim of this study was to compare the renal function measured with either 99mTc-DTPA or 99mTc-EC dynamic scintigraphies with that measured using 99mTc-DMSA static scintigraphy. METHODS the values of relative renal function measured in 111 renal dynamic scintigraphies performed either with 99mTc-DTPA (55 studies) or with 99mTc-EC (56 studies) were compared with the relative functi...

Contrast-enhancing magnetic resonance imaging with the liver-specific agent gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) has been shown to improve the detection rate of focal lesions. There is evidence from preclinical studies that multidrug organic anion transporters are involved in hepatic uptake of Gd-EOB-DTPA. Therefore, we evaluated affinity of the contrast age...

BACKGROUND We have previously demonstrated aerosol delivery during conventional and high frequency oscillatory (HFOV) ventilation using magnetic resonance imaging (MRI) in piglets. There are no reports on aerosol delivery during high frequency jet ventilation (HFJV). OBJECTIVE To compare delivery of aerosolized gadopentetate dimeglumine (Gd-DTPA) in 3 neonatal ventilator circuits: convention...