The alkylation of phosphates in DNA by therapeutically active haloethylnitrosoureas was studied by reacting N-chloroethyl-N-nitrosourea (CNU) with dTpdT, separating the products by HPLC, and identifying them by co-chromatography with authentic markers. Both hydroxyethyl and chloroethyl phosphotriesters of dTpdT were identified; a similar reaction between CNU and dTR yielded 3-hydroxyethyl and 3...

In this paper, a high data rate Ultra-Wideband Differential Transmitted-Reference (UWB-DTR) system which is one of the best and simplest available TR scheme is analyzed over IEEE 802.15.3a Channel Model 1 (CM1). We show that these systems need equalization in high data rate mode of operation because in such a case harsh nonlinear inter symbol interference (ISI) exists and degrades performance s...

This paper studies the bit error rate (BER) performance of non-coherent impulse-radio ultra wideband (IR-UWB) correlation receivers in the IEEE 802.15.3a channel for combined binary pulse amplitude modulation-pulse position modulation (BPAM-PPM) scheme. The BER performance is based on the channel averaged signal-to-noise ratio (SNR). The study includes simple transmitted reference (TR), differe...

Three experiments extended earlier findings on the impact of the Disrupt-Then-Reframe (DTR) technique on compliance. This technique is comprised of a subtle, odd element in a typical scripted request, the “disruption,” followed by a persuasive phrase, the “reframing.” Based on the thought-disruption hypothesis (Petty & Wegener, 1999), we argue that its impact is generalizable across situations ...

DTRs from February to June during the COVID-19 pandemic are greater than 3 standard deviations above climatological mean DTR.

the aim of this study was to determine the monthly dtr mass load of amphetamine-type compounds in poland as well as an investigation of cyclical behaviour by using time series analysis and especially trends analysis.amphetamine, methamphetamine and mdma (ecstasy) were detected in wastewater samples collected from the main wastewater treatment plant in the city of poznan using liquid chromatogra...

Previous studies on the impact of urbanization diurnal temperature range (DTR) have mainly concentrated intra-seasonal and interannual–decadal scales, while relatively fewer considered synoptic scales. In particular, modulation DTR by different weather patterns (SWPs) is not yet fully understood. Taking urban agglomeration Yangtze River Delta region (YRDUA) in eastern China as an example, using...

Cytotoxic T lymphocyte (CTL) has been found to be activated by cutaneous dendritic cell (DC) in inducible skin-associated lymphoid tissue (iSALT) a murine contact hypersensitivity (CHS) model. Cutaneous DCs are classified into Langerhans (LC), conventional DC1 (cDC1), DC2 (cDC2) and monocyte-derived DC (MoDC); however, which subsets activate CTL within iSALT during the elicitation phase of CHS ...

Abstract Tendons are composed of a heterogeneous cell environment, with Scleraxis-lineage (ScxLin) cells being the predominant population. Although ScxLin required for maintenance tendon homeostasis, their functions during healing unknown. To this end, we first characterized spatiotemporal dynamics healing, and identified that ov...