Calcineurin-dependent pathways have been implicated in the hypertrophic response of skeletal muscle to functional overload (OV) (Dunn, S.E., J.L. Burns, and R.N. Michel. 1999. J. Biol. Chem. 274:21908-21912). Here we show that skeletal muscles overexpressing an activated form of calcineurin (CnA*) exhibit a phenotype indistinguishable from wild-type counterparts under normal weightbearing condi...

PURPOSE Ovarian cancer remains a deadly malignancy because most patients develop recurrent disease that is resistant to chemotherapy. Organic anion-transporting polypeptides (OATPs) mediate the uptake of clinically important drugs thereby effecting intracellular drug accumulation. In this study, we investigated whether OATPs may also contribute to paclitaxel transport in estrogen-responsive and...

One-visit root canal treatment (OV-RCT) aims to preserve damaged teeth by fulfilling the principles of endodontic triad (cleaning and shaping, sterilizationand obturation) which are completed in OV; advantage is lower risk bacterial contamination, shorter time without compromising quality oftreatment results. This case report discusses OV-RCT man-dibular right second molar. A 23-year-old woman ...

In this work, oxygen vacancy-rich C/TiO2 (OV-C/TiO2) samples are prepared by a one-step calcination approach using Ti3C2 MXene as the precursor, and used for photocatalytic N2 reduction. The NH3 yields of all OV-C/TiO2 exceed those achieved on commercial anatase TiO2 P25, with both H2O CH3OH proton sources. Among them, OV-C/TiO2-600 offers remarkable synthesis rates, which 41.00 µmol g−1 h−1 (w...

Anorexie en ileus zijn frequent voorkomende postoperatieve complicaties bij konijnen potentieel fataal. Risicofactoren, zoals stress pijn, moeten zoveel mogelijk beperkt of vermeden worden. Om risicofactoren rondom het anesthesieprotocol orchidectomie ovario(hyster)- ectomie (OV(H)X) beter in beeld te brengen, werd een enquête rondgestuurd naar dierenartsen België Nederland. Uit de 209 ingevuld...

Underlying mechanisms associated with the development of abnormal metabolic phenotypes among obese individuals are not yet clear. Our aim is to investigate differences in plasma metabolomics profiles between normal weight (NW) and overweight/obese (Ov/Ob) individuals, with or without metabolic syndrome (MetS). Mass spectrometry-based metabolite profiling was used to compare metabolite levels be...

Oxide heterostructures have shown rich physics phenomena, particularly in the conjunction of exotic insulator–metal transition (IMT) at interface between polar insulator LaAlO3 and non-polar SrTiO3 (LaAlO3/SrTiO3). The polarization catastrophe model has suggested an electronic reconstruction, yielding to metallicity both surface. Another scenario is occurrence surface oxygen vacancy (surface-Ov...

Purpose:Oncolytic viruses (OV) based on herpes simplex virus type 1 (HSV1) are being used in clinical trials for a variety of cancers. The OV, rQNestin34.5, uses a nestin promoter/enhancer to selectively drive robust viral replication in malignant glioma cells. We have discovered that this promoter becomes extensively methylated in infected glioma cells, reducing OV efficacy. ExperimentalDesign...