With the aid of modern electromyography, numerous authors (Pabst and Esslen, I960; Sato, ig60; Orlowski and W6jtowicz, I962; Burger, I963; Blodi, van Allen, and Yarbrough, I964; Huber and Esslen, I969) have recently come to the (surprisingly) unanimous conclusion that a paradoxical innervation of the external rectus muscle of the affected eye represents the pathogenetic principle of all the ret...

BACKGROUND The number of retracted scientific publications has risen sharply, but it is unclear whether this reflects an increase in publication of flawed articles or an increase in the rate at which flawed articles are withdrawn. METHODS AND FINDINGS We examined the interval between publication and retraction for 2,047 retracted articles indexed in PubMed. Time-to-retraction (from publicatio...

With the aid of modern electromyography, numerous authors (Pabst and Esslen, I960; Sato, ig60; Orlowski and W6jtowicz, I962; Burger, I963; Blodi, van Allen, and Yarbrough, I964; Huber and Esslen, I969) have recently come to the (surprisingly) unanimous conclusion that a paradoxical innervation of the external rectus muscle of the affected eye represents the pathogenetic principle of all the ret...

Disconjugate oculomotor adaptation is driven by the need to maintain binocular vision. Since binocular vision in Duane Retraction Syndrome (DRS) patients is normal in half of their horizontal field of gaze (i.e., sound-side of gaze), we wondered whether oculomotor adaptive capabilities are efficient despite such a severe impairment of eye motility towards the other half of the horizontal field ...

CONTEXT Machado-Joseph disease (MJD), an autosomal dominant spinocerebellar degeneration caused by an expanded CAG repeat on chromosome 14q32.1, is a heterogeneous disorder for clinical manifestations. The reasons for the wide range of neurologic findings in this disease are poorly understood. OBJECTIVE To explain part of this heterogeneity through the association of the neurologic findings w...

The ocular motor system consists of three nerves which innervate six muscles to control eye movements. In humans, defective development of this system leads to eye movement disorders, such as Duane Retraction Syndrome, which can result from mutations in the α2-chimaerin signaling molecule. We have used the zebrafish to model the role of α2-chimaerin during development of the ocular motor system...

OBJECTIVES/HYPOTHESIS Although middle ear aeration is certainly related to eustachian tube (ET) function, other anatomic factors may play an important role in ventilation of these spaces, particularly the epitympanum. STUDY DESIGN A prospective case series study group with retrospective case series comparison. METHODS Eight patients affected by non-self-cleaning attic retraction pockets or ...

New techniques are described and illustrated for ptosis and lid retraction surgery in which the sutures holding the upper eyelid position are adjustable postoperatively. In the anterior approach, the sutures pass from the levator muscle through the anterior surface of the tarsal plate at the position of the skin crease and are tied at the skin crease incision. In the posterior approach, the sut...