Pharmaceuticals, which are designed to be biologically active at low concentrations, found in surface waters, meaning aquatic organisms can exposed complex mixtures of pharmaceuticals. In this study, the adverse effects four pharmaceuticals, 17?-ethynylestradiol (synthetic estrogen), methotrexate (anticancer drug), diclofenac (nonsteroidal anti-inflammatory drug) and fluoxetine (antidepressant)...