The treatment for closure of persistent ductus arteriosus (PDA) in adults still controversial. The endovascular approach has been shown as an effective alternative to surgical treatment. We report a case of 45 years old patient submitted to endovascular approach for PDA closure.

Reopening of the ductus arteriosus after successful indomethacin-induced closure has become a major problem with indomethacin treatment. In full-term human newborns and lambs, the ductus behaves like ischemic tissue after its initial constriction. Its ability to continue to relax or contract depends on the amount of left-to-right shunt through the ductus lumen. To see if ductus constriction in ...

CENTRAL SHUNTS EXIST IN THE fetal vascular system to enable circulation of enriched fetal blood. Delivery of metabolic wastes and gases to the placenta and return of oxygen and essential nutrients after exchange with maternal blood supply rely on these unique vascular channels. The ductus arteriosus is a large fetal vascular shunt situated between the pulmonary artery and aorta. It serves as th...

BACKGROUND Percutaneous closure of large persistent ductus arteriosus using the Amplatzer duct occluder is an alternative to surgery. However, this device is not recommended in infants weighing less than 6 kg. AIM To evaluate the safety and effectiveness of this procedure in low-body-weight infants. METHODS We reviewed retrospectively data for infants weighing less or equal to 6 kg who unde...

BACKGROUND At birth, the increase in oxygen causes contraction of the ductus arteriosus, thus diverting blood flow to the lungs. Although this contraction is modulated by substances such as endothelin and dilator prostaglandins, normoxic contraction is an intrinsic property of ductus smooth muscle. Normoxic inhibition of potassium channels causes membrane depolarization and calcium entry throug...

BACKGROUND Early fluid and electrolyte imbalances may be associated with an increased risk of bronchopulmonary dysplasia. OBJECTIVE We sought to establish an association between fluid and electrolyte balance in the first week of life and the risk of bronchopulmonary dysplasia. METHODS Clinical charts of 205 neonates <32 weeks gestational age and/or <1,250 g birth weight (admitted to our NIC...

T HE most frequent cardiovascular anomaly following maternal rubella is patent ductus arteriosus.1-0; The majority of patients with typical signs of patent ductus arteriosus are treated surgically without special diagnostic studies such as cardiac catheterization and angiocardiography. In these individuals residual systolic murmurs may persist and are often attributed to mild pulmonary valvular...

OBJECTIVES The aim of this study was to test the hypothesis that experimental maternal intake of green tea in late pregnancy causes fetal ductus arteriosus constriction, probably because of prostaglandin inhibition. METHODS AND RESULTS Twelve fetal lambs (pregnancy > 120 days) were assessed before and after maternal administration of green tea (n = 8) or water (n = 4; controls) as the only so...

Infants with aortic arch interruption of juxtaductal coarctation of the aorta may depend on patency of the ductus arteriosus to provide adequate lower body perfusion. In many such infants the ductus arteriosus constricts after birth, resulting in severe heart failure, poor systemic perfusion and acidemia. We infused prostaglandin E1 (PGE1) at a rate of 0.05--0.1 microgram/kg/min into seven infa...

The occurrence of various congenital anomalies, including heart defects, in children whose mothers had suffered from rubella during pregnancy was originally described by Gregg (1941) in Australia and these observations have been confirmed by many other workers. There is, however, surprisingly little detailed information available about the particular types of congenital heart defect that may oc...