نتایج جستجو برای: durable resistance

تعداد نتایج: 387540  

Journal: :New Phytologist 2021

Host plant defence mechanisms (resistance and tolerance) nutrition are two of the most widely proposed components for control hemiparasitic weeds genus Striga in tropical cereal production systems. Neither alone is effective enough to prevent parasitism concomitant crop losses. This review explores potential improved nutrition, being chemical constituent soil fertility, fortify expression inher...

2011
Sobia Tabassum

Stripe rust (yellow rust), caused by Puccinia striiformis f. sp. tritici is one of the most damaging diseases of wheat in Pakistan. Lack of durable resistance in local wheat varieties is the main reason for stripe rust epidemic which could limit yields. The use of genetically resistant wheat varieties is the most economic way of controlling the disease. Evaluation of 135 advance wheat lines for...

Journal: :Therapeutics and Clinical Risk Management 2009
Dolly G Aguilera Apostolia M Tsimberidou

Deregulated BCR-ABL tyrosine kinase (TK) activity is the molecular marker for chronic myeloid leukemia (CML), which provides an identifiable target for developing therapeutic agents. Imatinib mesylate, a BCR-ABL TK inhibitor, is the frontline therapy for CML. Despite the stunning efficacy of this agent, a small number of patients develop a suboptimal response or resistance to imatinib. In newly...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2001
M A Escobar E L Civerolo K R Summerfelt A M Dandekar

Crown gall disease, caused by the soil bacterium Agrobacterium tumefaciens, results in significant economic losses in perennial crops worldwide. A. tumefaciens is one of the few organisms with a well characterized horizontal gene transfer system, possessing a suite of oncogenes that, when integrated into the plant genome, orchestrate de novo auxin and cytokinin biosynthesis to generate tumors. ...

Journal: :Biomarkers in cancer 2015
Amit Dipak Amin Soumya S Rajan Matthew J Groysman Praechompoo Pongtornpipat Jonathan H Schatz

Acquired resistance to targeted inhibitors remains a major, and inevitable, obstacle in the treatment of oncogene-addicted cancers. Newer-generation inhibitors may help overcome resistance mutations, and inhibitor combinations can target parallel pathways, but durable benefit to patients remains elusive in most clinical scenarios. Now, recent studies suggest a third approach may be available in...

Journal: :Cancer discovery 2014
Hubing Shi Willy Hugo Xiangju Kong Aayoung Hong Richard C Koya Gatien Moriceau Thinle Chodon Rongqing Guo Douglas B Johnson Kimberly B Dahlman Mark C Kelley Richard F Kefford Bartosz Chmielowski John A Glaspy Jeffrey A Sosman Nicolas van Baren Georgina V Long Antoni Ribas Roger S Lo

BRAF inhibitors elicit rapid antitumor responses in the majority of patients with BRAF(V600)-mutant melanoma, but acquired drug resistance is almost universal. We sought to identify the core resistance pathways and the extent of tumor heterogeneity during disease progression. We show that mitogen-activated protein kinase reactivation mechanisms were detected among 70% of disease-progressive tis...

2009
Paul Turner

OSECO Inc., Brampton, ON. is pleased to announce that Bridgeport Chewings Fescue has been selected to enhance our line of cultivar turf seeds. Bridgeport is a new and .distinct, very dark green, Chewings Fescue. It has excellent resistance to leafs pot and powdery mildew. It has good resistance to red thread and stem rust. Bridgeport produces excellent qUality turf that stands up well against e...

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