The objective of the present study was to prolong the delivery of the active drug in the oral cavity using a suitable carrier such as in situ gel which can effectively deliver the drug for an extended duration of time hence not only reduce the systemic side effects but also improve the therapeutic efficacy, patient compliance. Buccal drug delivery systems are better suitable for antifungal drug...

This paper presents a probabilistic extension of Neighbourhood Logic (NL,[14, 1]). The study of such an extension is motivated by the need to supply the Probabilistic Duration Calculus (PDC, [10, 4]) with a proof system. The relation between the new logic and PDC is similar to that between DC [15] and ITL [12, 3]. We present a complete proof system for the new logic.

The purpose of the present work was to prepare buccal adhesive tablets of miconazole nitrate. The simplex centroid experimental design was used to arrive at optimum ratio of carbopol 934P, hydroxypropylmethylcellulose K4M and polyvinylpyrollidone, which will provide desired drug release and mucoadhesion. Swelling index, mucoadhesive strength and in vitro drug release of the prepared tablet was ...

This work describes a cryogenic, electro-optically -switched Yb:YAG laser that generates 114-W average TEM power with 47% optical-to-optical efficiency. Pulse repetition frequency is 5 kHz, pulse duration is 16 ns full-width at half-maximum, and is less than 1.05.

This work describes a cryogenic, electro-optically -switched Yb:YAG laser that generates 114-W average TEM power with 47% optical-to-optical efficiency. Pulse repetition frequency is 5 kHz, pulse duration is 16 ns full-width at half-maximum, and is less than 1.05.

   The objective of the present investigation was to develop and evaluate a contraceptive vagino-adhesive propranolol hydrochloride gel. To achieve this, various mucoadhesive polymers including guar gum (1-4% w/w), sodium alginate (4-7% w/w), xanthan gum (2-5% w/w ), HPMC 4000 (3-5% w/w), Na CMC (4-7% w/w), carbomer 934 and carbomer 940 both in the range of 0.5-2.0% w/w, were dispersed in an aq...

Insomnia is becoming increasingly prevalent in the world general population. Therapies used by patients include over-the-counter therapies, herbal and dietary supplements, and pharmacological or nonpharmacological treatments. Among these, zolpidem is a pharmacological treatment popularly used for insomnia. Zolpidem is well tolerated and especially efficacious for initiation of sleep, and theref...