Neuroscience shows why numbers-based HR management is obsolete.

I t's always wise to consult others before making a big decision, so a cell seeks input from a lot of different proteins before choosing between survival and death by apoptosis. Fricker et al. describe how one particular protein— cFLIP—can nudge a cell in either direction depending on the expression levels of its three different isoforms (1). Cells contemplate suicide in response to a number of...

In 2000 and 2002 after the ALLHAT-study had been published [1,2] there was a paradigm shift in the use of thiazides. ALLHAT was a study of cardiovascular endpoints in relation to different antihypertensive treatments in 33 357 hypertensive patients observed over an average of 4.9 years. The study [1,2] found no differences between the three treatment groups [diuretics in the form of chlorthalid...

Much of our knowledge of the basal mechanism underly-44 Lincoln's Inn Fields ing programmed cell death derives from the elegant London WC2A 3PX studies of Horvitz and colleagues on developmental cell United Kingdom death in the developmentally deterministic nematode worm Caenorhabditis elegans. During development of Apoptosis is the descriptive name given to the process the hermaphrodite worm, ...

A wide variety of cellular stresses can initiate apoptosis, or programmed cell death. Recent work shows that the mechanism involves stress-activated protein kinase pathways, although the targets of these pathways are unknown at present.

Donations The Jubilee Centre 3 Hooper Street, Cambridge CB1 2 NZ Tel: 01223 566319 Fax: 01223 566359 E-mail: [email protected] www.jubilee-centre.org Registered Charity No. 288783 1 Although this evidence was itself subsequently challenged. 2 His initial sentence of life imprisonment was subsequently reduced on appeal; Martin (2001), EWCA Crim 2245, 30 October 3

in this work, studies of underground gas storage (ugs) were performed on a partially depleted, naturally fractured gas reservoir through compositional simulation. reservoir dynamic model was calibrated by history matching of about 20 years of researvoir production. effects of fracture parameters, i.e. fracture shape factor, fracture permeability and porosity were studied. results showed that di...

Section 241(b) and s. 14 of the Criminal Code unjustifiably infringe s. 7 of the Charter and are of no force or effect to the extent that they prohibit physicianassisted death for a competent adult person who (1) clearly consents to the termination of life and (2) has a grievous and irremediable medical condition (including an illness, disease or disability) that causes enduring suffering that ...

L ysosomes spill their guts and kill their host cells, as revealed on page 231. Artal-Sanz et al. show that cells are more likely to escape a necrotic death sentence if they contain less acidic lysosomes. Necrosis—considered the unprogrammed counterpart to apoptotic death—is the deadly result of a severe and abrupt loss of energy, nutrients, or oxygen. These stimuli create sudden alterations in...

In today's knowledge economy, creativity is more important than ever. But many companies unwittingly employ managerial practices that kill it. How? By crushing their employees' intrinsic motivation--the strong internal desire to do something based on interests and passions. Managers don't kill creativity on purpose. Yet in the pursuit of productivity, efficiency, and control--all worthy busines...