For a wind energy system, main speed-increasing gearboxes, pitch drives and yaw are composed of multistage planetary gear system. However, inevitable errors in the manufacturing assembling gears lead to uneven load distribution system; thus, its service life reliability decrease greatly, which would eventually affect normal operation whole power In this study, dynamic sharing model drive is est...

In recent decades, the pervasiveness of increased arterial stiffness in patients with cardiovascular disease has become increasingly apparent. Though, this phenomenon has been well documented in humans and animal models of disease for well over a century, there has been surprisingly limited development in a deeper mechanistic understanding of arterial stiffness. Much of the historical literatur...

Directional mesenchymal cell invasion in vivo is understood to be a stimulated event and to be regulated by cytokines, chemokines, and types of extracellular matrix (ECM). Instead, by focusing on the cellular response to ECM stiffness, we found that soft ECM (low stiffness) itself is sufficient to prevent stable cell-to-cell adherens junction formation, up-regulate matrix metalloproteinase (MMP...

Arterial stiffening accompanies both aging and atherosclerosis, and age-related stiffening of the arterial intima increases RhoA activity and cell contractility contributing to increased endothelium permeability. Notably, statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors whose pleiotropic effects include disrupting small GTPase activity; therefore, we hypothesized...

Epithelial cells disengage from their clusters and become motile by undergoing epithelial-to-mesenchymal transition (EMT), an essential process for both embryonic development and tumor metastasis. Growing evidence suggests that high extracellular matrix (ECM) stiffness induces EMT. In reality, epithelial clusters reside in a heterogeneous microenvironment whose mechanical properties vary not on...

The performance of finite element computation depends strongly on the quality of the geometric mesh and the efficiency of the numerical solution of the linear systems resulting from the discretization of partial differential equation (PDE) models. It is common knowledge that mesh geometry affects not only the approximation error of the finite element solution but also the spectral properties of...

To assess the effects of halothane, isoflurane, and sevoflurane on cross bridges in intact cardiac muscle, electrically stimulated (0.25 Hz, 25 degrees C) right ventricular ferret papillary muscles (n = 14) were subjected to sinusoidal load oscillations (37-182 Hz, 0.2-0.5 mN peak to peak) at the instantaneous self-resonant frequency of the muscle-lever system. At resonance, stiffness is propor...

The problem of transient dynamics of highly flexible three-dimensional space-curved beams, undergoing large rotations and stretches, is treated. The case of conservative force loading, which may also lead to configuration-dependent moments on the beam, is considered. Using the three parameters associated with a conformal rotation vector representation of finite rotations, a well-defined Hamilto...

A frequency domain dynamic analysis is needed to obtain the response of structures constructed on a system of base isolators on flexible soil when subjected to earthquake ground motion. In such systems, the lateral stiffness of the base isolators is so small, compared to the structural stiffness, that in an earthquake attack the fundamental vibration mode dominates the response. With this in mi...

In this paper, following a two-stage methodology, the differential quadrature element (DQE) model of a three-story frame structure is updated for the vibration analysis. In the first stage, the mass and stiffness matrices are updated using the experimental natural frequencies. Then, having the updated mass and stiffness matrices, the structural damping matrix is updated to minimize the error be...