Red nail is a common disorder. However, a thorough examination of the patient's nails allows one to distinguish different diseases. For example, longitudinal erythronychia may be monodactylous or polydactylous. Only the former type can show histologically Bowen's disease or an amelanotic melanoma. Among the polydactylous type, the nosologic position of the acantholytic and dyskeratotic naevus v...

Nasopharyngeal carcinoma (NPC) occurs more frequently in patients with south-east Asian racial backgrounds. This disease may spreads superiorly to the skull base and intracranium followed by skull base destruction. We report a 56 year-old man presented with headache and diplopia. Magnetic resonance imaging (MRI) revealed extension of destructive mass from ethmoid sinus to the parenchyma. Intrao...

Darier disease, also known as keratosis follicularis or dyskeratosis follicularis, is a rare autosomal dominant genodermatosis. It is clinically manifested by hyperkeratotic papules primarily affecting seborrheic areas on the head, neck and thorax, with less frequent involvement of the oral mucosa. When oral manifestations are present, they primarily affect the palatal and alveolar mucosa, are ...

Darier's disease, also known as keratosis follicularis or dyskeratosis follicularis, is a rare disorder of keratinization. It is an autosomal dominant genodermatosis with high penetrance and variable expressivity. Its manifestation appears as hyperkeratotic papules primarily affecting seborrheic areas on the head, neck, thorax, and less frequently the oral mucosa. When oral manifestations are p...

Methods Mrs. E.F a 30 years old woman, was followed up, since 2003, for a lupus erythematous chronicus. In 2010, she presented a painful cheilitis of the upper lip that gradually increases in volume. Clinical examination showed a scaly macrocheilitis, the rest of the clinical examination was within normal limits. The labial biopsy showed a dyskeratotic hyperkeratosis, keratotic plugs, a pseudo-...

Abstract Background A hypertrophic / vegetating variant of Darier disease causing massive verruciform genital tumors is exceedingly rare. Case presentation woman in her late 50s underwent wide resection vulva and inguinal skin due to lesion. She had crusted keratotic plaques with appearance follicular keratosis (with a greasy, warty texture) the back, neck, face, extremities for 27 years. Previ...

Porokeratosis represents a spectrum of clinical diseases. Multiple variants have been described including porokeratosis ptychotropica, a rare subtype. The coexistence of two or more variants of porokeratosis in a single patient is regarded as a rare occurrence. Here we report a patient with porokeratosis ptychotropica with coexistent porokeratosis of Mibelli. The patient was a 47-year-old man w...