We have recently developed target-specific derivatization methods for determining the metabolites in human nails. The nails can be used to obtain physiologic information and may serve as noninvasive biosamples for the diagnosis of chronic disease. Certain endogenous biogenic D,L-amino acids, polyamines, and advanced glycation end-products (AGEs) have been detected in human nails. By identifying...

BACKGROUND Renal transplant recipients (RTR) are regarded as a group especially predisposed to onychomycosis. The exact mechanism of increased frequency of onychomycosis in RTR is however not fully understood. OBJECTIVES This study was undertaken to evaluate activity of hydrolitic enzymes of fungi most commonly causing fungal nail infections in RTR and to compare it with enzymatic activity of...

Six years ago a patient suffered a severe allergic reaction from sensitization to methyl methacrylate in a mixture of materials designed to make artificial nails. There was marked erythema, edema, and pain of the eponychial and paronychial tissues with persistent paresthesia of the finger tips. Gradual destruction of the nail plates developed and since no regrowth of the nails resumed in six ye...

A 19 year old male, student, presented with a history of progressive loss of vision from right eye since one and half year and from the left eye since one year. The patient also complained of multiple episodes of generalized seizures three months back. Patient was diagnosed with tubercular choroiditis with chronic kidney disease with seizure disorder. The patient was evaluated but no intracrani...

It will be noted from the large standard deviations of the top half of Table 1 that the material proved rather variable. There are some indications that 3,3-tetramethyleneglutarate has a greater effect on fructose pool size in dystrophic muscle, but this cannot be proved statistically on this sample. The lower half of Table 1 shows an effect of 3,3tetramethyleneglutarate on fructose labelling, ...

AIMS To describe the ophthalmic findings in a large cohort of epidermolysis bullosa (EB) patients managed in one large specialist centre. METHODS A case note review of consecutive patients seen at Great Ormond Street Children's Hospital. Data on the dermatological disease, ophthalmic history, and examination were collected and coded onto a data sheet. RESULTS 181 patients: 50 (28%) simplex ...

We have systematically reviewed the effect of alternative methods of stabilisation of open tibial fractures on the rates of reoperation, and the secondary outcomes of nonunion, deep and superficial infection, failure of the implant and malunion by the analysis of 799 citations on the subject, identified from computerised databases. Although 68 proved to be potentially eligible, only eight met a...

We have systematically reviewed the effect of alternative methods of stabilisation of open tibial fractures on the rates of reoperation, and the secondary outcomes of nonunion, deep and superficial infection, failure of the implant and malunion by the analysis of 799 citations on the subject, identified from computerised databases. Although 68 proved to be potentially eligible, only eight met a...

Raman spectroscopic comparisons of erythrocyte membranes from 20 patients with Duchenne muscular dystrophy and 8 age-matched controls indicate a prominent and consistent protein anomaly in the patient samples. This was apparent in the following: (a) CH-stretching signals from control membranes reveal a thermotropic transition at 15.6 degrees C, attributable to a protein/lipid phase that is lack...