Urinary bladder tumours in cattle are caused by chronic ingestion of bracken fern and BPV-1/2 infection. The objective of the present study was to assess if BPV-2 was present in urinary bladder lesions from cattle with chronic enzootic haematuria (CEH) from the Azores archipelago (Portugal), in order to gain further information regarding the epidemiologic distribution of this virus. Samples wer...

Recently, with the advance of human genome decoding and pharmacogenomics, issues on ethnic and population differences have taken the center stage in the new drug approval process. Since most of the new medicines were developed in western countries, the efficacy and safety of a drug was generally established based on Caucasian majority. Whether the foreign clinical data could be naively extrapol...

X-ray sensitive Chinese hamster V79 cells mutants, V-C4, V-E5 and V-G8, show an abnormal response to X-ray-induced DNA damage. Like ataxia telangiectasia (AT) cells, they display increased cell killing, chromosomal instability and a diminished inhibition of DNA synthesis following ionizing radiation. To localize the defective hamster gene (XRCC8) on the human genome, human chromosomes were intr...

In Tetrahymena thermophila, highly phosphorylated histone H1 of growing cells becomes partially dephosphorylated when cells are starved in preparation for conjugation. To determine the effects of H1 phosphorylation on gene expression, PCR-based subtractive hybridization was used to clone cDNAs that were differentially expressed during starvation in two otherwise-isogenic strains differing only ...

Human papillomavirus type 16 (HPV16) is the major cause of cervical cancer and of a fraction of oropharyngeal carcinoma. Few studies compared the viral expression profiles in the two types of tumor. We analyzed HPV genotypes and viral load as well as early (E2/E4, E5, E6, E6*I, E6*II, E7) and late (L1 and L2) gene expression of HPV16 in cervical and oropharyngeal cancer biopsies. The study incl...

The earliest detectable mammalian prespliceosome complex (E) contains the non-snRNP splicing factor U2AF, U1 snRNP, and several spliceosome-associated proteins (SAPs). We show that specific complexes, designated E3' and E5', assemble independently on RNAs containing only a 3' or 5' splice site, respectively. U2AF is enriched in E3', whereas U1 snRNP is enriched in E5'. Using a highly sensitive ...

By using an effective complex algorithm to calculate the Lyapunov constants of polynomial systems En: ż = iz + Rn(z, z̄), where Rn is a homogeneous polynomial of degree n, in this note we construct two concrete examples, E4 and E5, such that in both cases, the corresponding orders of fine focus can be as high as 18. The systems are given, respectively, by the following ordinary differential equa...

The purpose of this paper is to evaluate the recent developments in the theory and practice of monetary policy, drawing on the work of influential monetary economists of the past. JEL Classification: E5, E52

Abstract Objectives: To diagnose thyroid cancer, ultrasonography is a primary tool, but diagnostic accuracy varies according to the proficiency of clinicians. The aim this study was compare performance between deep convolutional neural network (CNN) models and endocrinologist with various experiences. Methods: Patients who underwent fine needle aspiration at endocrinology department in Seoul Na...

The equine sarcoid, a locally aggressive, fibroblastic skin tumour, is the most common dermatological neoplasm reported in horses; there is no consistently effective therapy. It is widely accepted that bovine papillomavirus (BPV) types 1 and 2 are associated with the pathogenesis of sarcoid disease. Most sarcoids appear to contain detectable viral DNA and RNA and are also known to express the B...