Tissue type plasminogen activator (t-PA) is an effective thrombolytic agent in experimental animals. The duration of the thrombolytic effect of infused t-PA is unknown. We compared the duration of the thrombolytic effect of t-PA with streptokinase by measuring the lysis of 125I-fibrin-labeled thrombi in rabbit jugular veins at different times after a bolus injection of the fibrinolytic agents. ...

Renal functional reserve, microalbuminuria, and plasma atrial natriuretic factor were measured in 21 offspring (9.5±0.5 years of age, mean±SEM) of hypertensive parents and in eight children (10±0.5 years of age) with no family history of hypertension who were used as a control group. Renal functional reserve was evaluated by measurement of the changes in creatinine clearance after an oral prote...

BMJ 2007;335:719-20 doi: 10.1136/bmj.39331.702951.47 • Age under 1 year and presence of bruise, swelling, or laceration (>5 cm) on the head • Dangerous mechanism of injury • Clinical suspicion of non-accidental injury • Loss of consciousness lasting more than fi ve minutes (witnessed) • Post-traumatic seizure but no history of epilepsy • Abnormal drowsiness • Suspected open or depressed skull i...

To investigate whether the response of salt-regulating hormones to volume expansion is impaired in obese subjects, we assessed the effects of saline load (0.25 mL/kg.min.120 min) in 9 young, healthy, normotensive obese subjects (body mass index, > 30 kg/m2) and in 10 lean control subjects (body mass index, < 25 kg/m2) matched for age, gender, height, and mean blood pressure. Hematocrit, plasma ...

In the present study cardio-vascular adaptation to graded exercise was studied in untrained male medical students. The subjects were given two grades of exercise each lasting for about five minutes with a rest of fifteen minutes in between on a mechanically braked bicycle ergometer. There was a statistically significant rise in the heart rate during both the exercise sessions. This rise was per...

Among the many factors that affect ventilatory function in the asthmatic subject, physical exercise and bronchodilator drugs are two of the more important. It has been shown that physical exercise has two distinct and opposite effects on ventilatory function depending upon the duration and level of exercise (Jones, Buston and Wharton, 1962). Providing the level is adequate, exercise lasting les...