Alzheimer’s disease (AD) is the most common form of dementia and phenotypically heterogeneous. APOE a triallelic gene which correlates with phenotypic heterogeneity in AD. In this work, we determined effect alleles on progression timeline AD using discriminative event-based model (DEBM). Since DEBM data-driven model, stratification into smaller subgroups would lead to more inaccurate models as ...

BACKGROUND Presenile dementia of alzheimer type is a rare condition, and a report drawn from a large population may be useful to general practitioners. AIM A study was undertaken in the Northern Regional Health Authority area to investigate general practitioner referral practice, hospital investigations and diagnosis in cases of presenile alzheimers disease. METHOD Reviews of 186 sets of ca...

1. Porteri C, Galluzzi S, Geroldi C, Frisoni GB. Diagnosis disclosure of prodromal Alzheimer disease – ethical analysis of two cases. Can J Neurol Sci. 2010; 37: 67-75. 2. Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J, et al. Research criteria for the diagnosis of Alzheimer’s disease: revisiting of the NINCDS-ADRDA criteria. Lancet Neurol. 2007; 6: 734-46. 3. Gauthi...

neurodegenerative disorders such as huntingtons disease, alzheimers disease, parkinsons disease, amyotrophic lateral sclerosis, spinal muscular atrophy, friedreichs ataxia, and others are multi-factorial illnesses in which many pathways (still poorly understood) act serially and in parallel to give a determined pathologic phenotype. thus, presently there are no effective cures for these disease...

Will reading habit influence your life? Many say yes. Reading american psychiatric publishing textbook of alzheimers disease and other dementias the app textbook of geriatric psychiatry diagnostic issues in dementia is a good habit; you can develop this habit to be such interesting way. Yeah, reading habit will not only make you have any favourite activity. It will be one of guidance of your li...

Although the vast majority of Alzheimer’s disease (AD) cases are of the sporadic type, mutations causing the familial form have been the focus of AD research for decades. The disease is pathologically characterised by β-amyloid (Aβ) and tau protein aggregates in neuritic plaques and neurofibrillary tangles. Furthermore, it is known that AD pathology spreads throughout the brain, most often alon...